2024年12月25日 · TUBA4A (Tubulin Alpha 4a) is a Protein Coding gene. Diseases associated with TUBA4A include Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal …

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene. [5] Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are …

2022年7月20日 · We found that Tuba4a lacking C-terminal polyglutamylation prevents the binding of Tau and GSK3 kinase to neuronal microtubules, thereby strongly reducing phospho-Tau …

2025年2月9日 · Tandem affinity purification and mass spectrometry analysis identify tubulin alpha 4a protein (TUBA4A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP …

2023年8月23日 · We identified three isolated patients with heterozygous variants in the TUBA4A gene (Fig. 1A). The proband in Trio 1 carried a c.850G > A;p.E284K variant, which was …

The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset. …

通过补充一定剂量的野生型tuba4a，可显著恢复突变造成的阻滞作用，提高卵母细胞的成熟比例和受精卵发育至囊胚的比例。该研究揭示了因tuba4a突变导致女性不孕的分子机制并寻找到了潜 …

Microtubules of the eukaryotic Cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule …

2016年9月14日 · Gene target information for TUBA4A - tubulin alpha 4a (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2021年5月18日 · We identified a likely pathogenic variant in TUBA4A segregating with disease. TUBA4A encodes for α-tubulin, which is a major component of the microtubule network. …