Neuromuscular blocking drugs: discovery and development
Oscar Wintersteiner and James Dutcher in 1942 were the first to isolate the alkaloid d-tubocurarine from biologically authenticated samples of Chondrodendron tomentosum 12. A H …
仅显示来自 pmc.ncbi.nlm.nih.gov 的搜索结果Neuromuscular block - PMC - PubMed Central (PMC)
Neuromuscular blocking drugs, in particular curare and its most important purified alkaloid tubocurarine, are a prime example illustrative of the clos…
Tubocurarine chloride - Wikipedia
Tubocurarine (also known as d-tubocurarine or DTC) is a toxic benzylisoquinoline alkaloid historically known for its use as an arrow poison. In the mid-1900s, it was used in conjunction with an anesthetic to provide skeletal muscle relaxation during surgery or mechanical ventilation. Safer alternatives, such as cisatracurium and rocuronium, have largely replaced it as an adjunct fo…
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Neuromuscular block - PMC - PubMed Central (PMC)
Neuromuscular blocking drugs, in particular curare and its most important purified alkaloid tubocurarine, are a prime example illustrative of the close liaison that has been and continues …
Tubocurarine - an overview | ScienceDirect Topics
Following the discovery of penicillin by Fleming in 1929 – described by Mann (1984) as ‘the most important medical discovery of all time’ – and its development as an antibiotic for clinical use …
筒箭毒碱 - 百度百科
- 双苄基异喹啉生物碱
一种双苄基异喹啉生物碱。存在于防己科植物中，为筒箭毒的主要有毒成分之一。1879年R.伯姆首先提纯。其无水物熔点274～275℃（分解）;含5分子结晶水的水合物约在270℃分解，比旋光度【α】+190°（0.5克/100毫升水），算出无水物的【α】+215°；在水中的溶解度为50毫克/毫升(2…
- 双苄基异喹啉生物碱
A History of Neuromuscular Block and Its Antagonism
In 1935, Harold King (1887–1956) extracted tubocurarine from a crude preparation of unknown origin. From the information he gathered, he published an erroneous chemical structure of …
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T3DB: Tubocurarine
2009年7月23日 · Tubocurarine is a type of curare, a plant toxin known for its use as paralyzing arrow poison by South American indigenous people. It can be extracted from a variety of …
Tubocurarine - SpringerLink
2018年11月20日 · Tubocurarine is a kind of alkaloid isolated from various plant extract alkaloid arrow poisons which has a common name curare. The active dextrorotatory form was first …
Repositioning of tubocurarine as analgesic and anti-inflammatory …
2022年11月1日 · Tubocurarine (d-TC), a non-depolarizing competitive blocker of nicotinic acetylcholine receptors is extensively utilized for the relaxation of skeletal muscles. Drug …
Tubocurarine – eDrug
Tubocurarine is a plant alkaloid that, although not used clinically in the modern era is a prototype for other drugs that block the neuromuscular junction. It is a slow onset, long-acting, non …
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