2011年9月14日 · Recent studies have identified a large group of Tudor proteins that are primarily expressed in the germ line, where they interact with arginine-methylated PIWI proteins and …

2009年12月1日 · We show that several germline Tudor proteins are physiological binding partners of the Piwi family. In particular, we identify Tdrkh as a novel Miwi-interacting protein that binds …

2011年3月23日 · PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that protect the integrity of the genome by silencing transposable elements in both germline …

2010年8月24日 · What is the Tudor domain? The Tudor domain was first identified as a segment of approximately 60 amino acids that is present in 11 repeated units in the Drosophila protein …

Here, we identify Tudor domain-containing 12 (TDRD12; also known as ECAT8) as a unique piRNA biogenesis factor in mice. TDRD12 is detected in complexes containing Piwi protein …

2017年11月8日 · We used crystallography and biochemical studies to show that TDRD2 binds to PIWI-like protein 1 (PIWIL1) in an arginine methylation-independent manner. Our complex …

A major function of the TDRD proteins is to recognize the N-terminal arginine-rich motifs of the P-element-induced wimpy testis (PIWI) proteins via their conserved extended Tudor (eTudor or …

2021年10月8日 · Tudor domain-containing (TDRD) proteins, the germline enriched protein family, play essential roles in the process of gametogenesis and genome stability through their …

Here, we discuss the emerging roles of Tudor domain proteins during development, most notably in the Piwi-interacting RNA pathway, but also in other aspects of RNA metabolism, the DNA …

2016年1月25日 · Here we show that Drosophila Piwi interacts with a special Tudor-domain-containing protein called Tudor-SN (Tudor staphylococcal nuclease, TSN). TSN is drastically …