2020年10月27日，福州大学生命科学研究所的杨宇丰课题组为主的多家合作研究单位在Molecular Cell杂志在线发表了题为”Paradoxical Mitophagy Regulation by PINK1 and TUFm ”的研究论文，作者通过生物化学、遗传学、细胞生物学、活体疾病模型以及数学建模等多种研究方法 ...

2024年12月25日 · TUFM (Tu Translation Elongation Factor, Mitochondrial) is a Protein Coding gene. Diseases associated with TUFM include Combined Oxidative Phosphorylation Deficiency 4 and Mitochondrial Disease. Among its related pathways …

2024年5月28日 · Tu translation elongation factor, mitochondrial (TUFM, also known as P43; EF-TU; EFTU; COXPD4; EF-Tu MT) is a nuclear-encoded mitochondrial protein participating in mitochondrial polypeptide biosynthesis. Of note, TUFM is one of the most abundant proteins in the mitochondria and the bacterial cell (1 – 3).

Tufm 是线粒体自噬的一个关键因素，经过筛选并确定大部分是乳酸化的。 检测到 Tufm 在 K286 位点被乳酰化，乳酰化抑制 Tufm 和 Tomm40 在线粒体上的相互作用。

2021年1月4日 · Kaem directly interacted with the mitochondrial elongation factor TUFM, and TUFM absence reversed Kaem-induced autophagy and lipid degradation. Kaem also induced mitochondrial reactive oxygen...

该基因编码一种参与线粒体蛋白质翻译的蛋白质。 该基因的突变与导致乳酸性酸中毒和致命性脑病的联合氧化磷酸化缺陷有关。 已在 17 号染色体上鉴定出假基因。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined Oxidative Phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy.

TUFm传统上被认为是一个核编码的线粒体蛋白翻译延伸因子。 研究发现PINK1通过磷酸化TUFm的一个保守丝氨酸位点，可将TUFm的促线粒体自噬功能转变为抑制功能。

TUFM为重要的mtDNA修复蛋白，可对线粒体中损伤的mtDNA进行修复，其在细胞质和线粒体均有分布[10-11]。 通过构建结构域突变的质粒，进而通过免疫共沉淀、临位连接PLA技术及免疫荧光共定位进一步证实，FUNDC1可通过其95-133氨基酸位点的结构域与TUFM结合，该结构域 ...

TUFM (Tu translation elongation factor, mitochondrial) is a nuclear-encoded mitochondrial protein translation elongation factor that plays a critical role in maintaining normal mitochondrial function. The variant position was highly conserved among species and predicted to be disease causing.

TUFM is a novel regulator of epithelial-mesenchymal transition (EMT); there may be a molecular link between mitochondrial dysfunction and EMT induction; NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. Increased expression of TUFM is a promising new prognostic indicator for colorectal carcinoma.