Targeting DNA damage response pathways in cancer - Nature
2022年12月5日 · Cells have evolved a complex network of biochemical pathways, collectively known as the DNA damage response (DDR), to prevent detrimental mutations from being …
DNA Damage/Repair Management in Cancers - PMC - PubMed …
Cancer chemotherapy and radiotherapy are designed to cause apoptosis in cancer cells by inducing catastrophic DNA damage such as DSBs. Traditional therapeutic strategies have …
DNA Damage Response in Cancer Therapy and Resistance: …
DNA damage induced in cancer cells upon radiation or chemotherapy leads to the release of chromosome fragments or small pieces of DNA that activate an immune response. When …
DNA damage repair: historical perspectives, mechanistic pathways and ...
2021年7月9日 · In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, then we …
DNA repair mechanisms in cancer development and therapy
When mutations affect tumor suppressor genes or oncogenes, cell might transform into cancer cells. Therefore, DNA repair is essential for preventing tumor development. However, once a …
The injury response to DNA damage in live tumor cells promotes …
2021年10月19日 · Here, we identified one such modality by using DNA damage to create a live, injured tumor cell adjuvant. Using an optimized ex vivo coculture system, we found that …
DNA damage and the balance between survival and death in cancer …
2015年12月18日 · DNA is vulnerable to damage resulting from endogenous metabolites, environmental and dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer …
The DNA Damage Response and Inflammation in Cancer
2023年7月7日 · Indeed, DDR signaling in cancer cells has been consistently linked to the inhibition of tumor-targeting immune responses. Here, we discuss the complex interactions …
The injury response to DNA damage in live tumor cells promotes …
2021年10月19日 · Here, we identified one such modality by using DNA damage to create a live, injured tumor cell adjuvant. Using an optimized ex vivo coculture system, we found that …
DNA repair and genetic instability - World Cancer Report - NCBI …
Environmental exposures and reactive species generated during normal cellular processes can damage DNA, which can lead to genetic instability. DNA damage repair and signalling …