A tumor (neoplasm) is a solid mass of tissue that forms when abnormal cells group together. They can form most anywhere in your body, including your bones, skin, tissue, organs and glands. Many tumors are benign, which means they’re not cancer.

2024年3月19日 · Changes in molecular-level, cellular-level and tissue-level mechanical properties across multiple timescales and dimensions play a critical role in driving oncogenesis, tumour organization and...

Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for effective cancer prevention and therapy.

2025年1月15日 · Recently, we proposed four physical hallmarks of cancer, with distinct origins and consequences, to characterize abnormalities in the physical tumor microenvironment: (1) elevated...

2023年10月20日 · Solid tumors and their associated tumor microenvironment (TME) consist of tumor cells and stromal components, including extracellular matrix (ECM), basement membrane (BM), vasculature, immune...

Morphological and functional characteristics of the malignant cell. Morphologically, the cancerous cell is characterized by a large nucleus, having an irregular size and shape, the nucleoli are prominent, the cytoplasm is scarce and intensely colored or, on the contrary, is pale.

Although some tumors (eg, leukemias, ascites tumors) grow as cell suspensions, most tumors grow as solid masses of tissue. Solid tumors have a distinct structure that mimics that of normal tissues and comprises two distinct but interdependent compartments: the parenchyma (neoplastic cells) and the stroma that the neoplastic cells induce and in ...

2024年7月29日 · A tumor, or neoplasm, is abnormal tissue that develops because of excessive cell growth. Tumors can be either benign (noncancerous) or malignant (cancerous and likely to spread to other parts of the body).

2025年3月12日 · Tumors often exhibit greater stiffness compared to normal tissues, primarily due to increased deposition within the tumor stroma. Collagen, proteoglycans, laminin, and fibronectin are key components of the extracellular matrix (ECM), interacting to facilitate ECM assembly. Enhanced fiber density and cross-linking within the ECM result in elevated matrix stiffness and interstitial fluid ...

2 天之前 · Tumor cell-derived OPN positively correlated with the degree of tumor stromal fibrosis. (A) Representative immunohistochemical (IHC) staining images (left, scale bars = 20 μm) and the quantification (right) of αSMA and Sirus red-stained images in 4T1 WT and 4T1 Spp1 − KO tumor tissues of Balb/c mice (n = 3).Original magnification, ×500.