2021年5月5日 · To map the cell type-specific transcriptome landscape of cancer cells and their tumor microenvironment in advanced non-small cell lung cancer (NSCLC), we analyze 42 tissue biopsy samples from...

2023年3月14日 · We combined transcriptional data from five different datasets for adult glioma, pediatric tumors and healthy normal brain regions, corrected for batch effects, and used a dimension reduction...

The spatial UMAP dimensionality reduction approach allows for unsupervised clustering of multifaceted spatial arrangements within the tumor microenvironment, including those associated with clinical outcome.

2024年9月27日 · Employing Mugen-UMAP, we analyzed whole-exome sequencing data from 365 single-cell samples across 12 non-small cell lung cancer (NSCLC) patients, revealing distinct clusters associated with histological subtypes of NSCLC.

2021年12月27日 · In this study, we leveraged a unique dataset composed of both cell type compositional and transcriptomic data from 364 fresh surgical specimens across 12 tumor types to identify conserved tumor immune archetypes.

2025年2月25日 · Aging promotes tumor growth and alters CD8+ T cell fate and effector function. . e, Galaxy plots depicting the cell density in UMAP space for tumor-infiltrating CD8+ T cells from young (left) and aged (right) tumor-bearing mice.

2 天之前 · (A-B) Representative flow cytometry histograms (A) and statistical analysis (B; n = 6) displayed the expression of JAG2 in tumor and immune cell subpopulations within tumor tissue. (C) UMAP of neutrophils displayed nine subtypes. Each dot represents a single cell, color-coded by cell origins (left) and cell clusters (right).

4 天之前 · Intratumoral microbiota activated anti-tumor immune. A UMAP plots of 7 cell types identified by scRNA-seq of 6 TNBC samples. B The top 3 marked genes of each cell type. C Statistical histograms of each cell type in pCR and non-pCR groups. D UMAP plots of 5 subclusters of macrophages.

A spatial uniform manifold approximation and projection (UMAP) was constructed using the image cytometry output. Spatial UMAP subtraction analysis (survivors vs. nonsurvivors at 5 years) was used to identify topographic and coexpression signatures …

2025年2月1日 · Immunostaining of squamous cell carcinoma specimens from patients with IP demonstrated that the tumors expressed NR3C1 to varying degrees. Furthermore, higher NR3C1 expression levels were associated with a significantly increased risk of recurrence. Our results point to a novel subtype of lung squamous cell carcinoma.