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We conducted an open label, dose escalation Phase 1 clinical trial of a tetravalent dengue DNA vaccine (TVDV) formulated in Vaxfectin ® to assess safety and immunogenicity.

We conducted an open label, dose escalation Phase 1 clinical trial of a tetravalent dengue DNA vaccine (TVDV) formulated in Vaxfectin ® to assess safety and immunogenicity.

2025年1月1日 · Although the CYD-TDV (Dengvaxia®) vaccine with an overall vaccine efficacy of 60 % has been licensed for clinical use since 2015, it poses an elevated risk of severe dengue infections especially in dengue-naïve children below 9 years of age.

2018年1月22日 · We conducted an open label, dose escalation Phase 1 clinical trial of a tetravalent dengue DNA vaccine (TVDV) formulated in Vaxfectin® to assess safety and immunogenicity.

In phase 1 clinical trials, a TVDV with Vaxfectin ® (Vical, Boulder, CO, USA) adjuvant was found to trigger anti-dengue T cell IFNγ response with ideal safety . DNA vaccines are stable, easy to prepare, low in cost, and suitable for mass production but lack high immunogenicity.

Definition of TVDV in Military and Government. What does TVDV stand for?

2020年6月3日 · TVDV infused into macaques salivary glands elicited a significantly weaker antibody response than with different delivery methods. Keywords: DNA vaccine; Non-human primate; Salivary gland infusion; Tetravalent dengue vaccine.

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2011年12月15日 · Currently, several different approaches are being taken to develop a protective tetravalent dengue vaccine. These include live-attenuated vaccines derived by serial passage in tissue culture, live chimeric vaccines, recombinant protein vaccines and DNA vaccines.