Twist-related protein 1 (TWIST1) also known as class A basic helix–loop–helix protein 38 (bHLHa38) is a basic helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene. [5] [6]

2024年12月25日 · TWIST1 (Twist Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with TWIST1 include Saethre-Chotzen Syndrome and Craniosynostosis 1. Among its related pathways are Gene expression (Transcription) and Signaling by ALK fusions and activated point mutants.

TWIST1 is a basic helix-loop-helix (bHLH) transcription factor which plays essential and pivotal roles in multiple stages of embryonic development, and significantly contributes to tumor metastasis, even tumor initiation and primary tumor growth. It is well recognized that TWIST1 is overexpressed in a variety of tumors.

「Twist1」是一种具有螺旋–环–螺旋（helix-loop-helix，bHLH）结构的转录因子，与胚胎早期发育密切相关，同时通过增强上皮间质转化（epithelial mesenchymal transition，EMT）促进卵巢癌、前列腺癌以及胰腺癌等…

2011年8月30日 · Twist1 is a basic helix-loop-helix domain-containing transcription factor. It forms homo- or hetero-dimers in order to bind the Nde1 E-box element and activate or...

扭曲家族 bHLH 转录因子 1： 该基因编码在胚胎发育中起重要作用的基本螺旋-环-螺旋 (bHLH) 转录因子。 编码的蛋白质形成同源二聚体和异源二聚体，它们与 DNA E 盒序列结合并调节颅骨发育过程中参与颅缝闭合的基因的转录。

Twist家族包括Twist1和Twist2两种基因，通常指Twist即为Twist1。 尽管Twist1在癌发生及上皮-间质转化(epithelial to mesenchymal transition，EMT)中的作用研究较多，但越来越多的证据表明，Twist1在非上皮性肿瘤的进展及预后中同样发挥着重要作用。

TWIST1 regulates proliferation, migration, and invasion and is a prognostic marker for oral tongue squamous cell carcinoma. Twist1-YY1-p300 complex promotes the malignant progression of HCC through activation of miR-9 by forming phase-separated condensates at super-enhancers and relieved by metformin.

2025年3月8日 · TWIST1 rescue calcium overload and apoptosis induced by inflammatory microenvironment in S. aureus-induced osteomyelitis. USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination. Targeting epithelial cell-derived TWIST1 alleviates allergic asthma. Twist1 as a target for prevention of cutaneous squamous cell carcinoma.

twist1，即扭曲螺旋转录因子1，别名twist、twistl1等。 它是一种由TWIST1基因编码的转录因子，属于基本螺旋-环-螺旋(bHLH)超家族成员，在多种组织中表达。 TWIST1的作用机制主要是通过结合到特定DNA序列上的E-box元件，调控下游基因的表达，影响细胞的增殖、分化和 ...