2019年10月14日 · The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.

2019年10月14日 · To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use ...

Type 1 diabetes status was assigned according to clinician diagnosis. Samples labeled Caucasian (non-Hispanic) in the original publication. Total sample number contains the number of controls, cases, and includes the number of first/second... -degree relatives and samples identified as "at risk" (autoantibody positive) used in other analyses.

2020年9月1日 · Type I PGS (PGS-1) is an uncommon clinical entity that results from an interarytenoid adhesion/scar band that is separate from the posterior interarytenoid mucosa. We present a case series of patients with PGS-1 treated at our institution to contribute to the understanding of this complex clinical entity.

Polygenic risk scores (PRS) quantify the genetic liability to disease and are calculated using an individual's genotype profile and disease-specific genome-wide association study (GWAS) summary statistics. Type 1 (T1D) and type 2 (T2D) diabetes both are determined in …

2024年6月14日 · Introduction: Type 1 diabetes (T1D) and type 2 diabetes (T2D) polygenic risk scores (PGS T1D and PGS T2D) can differentiate T1D and T2D, but it remains unclear whether PGS T1D and PGS T2D can inform T2D treatment and disease severity.

Type 1 Diabetes Mellitus is a T cell-mediated autoimmune disease - the main cause is an imbalance between T regulatory and autoreactive CD4 + and CD8 + T effector cells, which make them react specifically against pancreatic islet-associated …

2024年4月8日 · Type 1 polyglandular syndrome targets endocrine and nonendocrine tissues in an autoimmune-destructive process. Our case report is about a 27-year-old male who came with complaints of fever, dysarthria, and dysphagia and presented with oral candidiasis and nail dystrophy, along with complaints of alopecia since he was 7 years old, progressively ...

Here we investigated the effects of prostaglandins (PGs) on signal transduction in purified primary cultures of rat type-1 and type-2 astrocytes. PGF2 alpha, PGD2, and 9 alpha,11 beta-PGF2, a metabolite of PGD2 and a stereoisomer of PGF2 alpha, evoked a rapid rise in the intracellular Ca2+ concentration ([Ca2+]i) in type-1, but not in type-2 ...

Type 1 diabetic patients were characterized by insulin dependency, a history of diabetic ketoacidosis, autoantibody positivity, and onset at < 35 yr of age. Established type 2 diabetic patients presented clinically as initially treatable with oral hypoglycemic agents, autoantibody negative, with C-peptide > 2 ng/dL, and onset > 35 yr of age.