我们知道DNA的甲基化修饰是发生在胞嘧啶（C）上的，而最常见的RNA的甲基化修饰是 m6A （N6-methyladenosine，6-甲基腺嘌呤）和 尿苷化修饰 （uridylation，U-tail）。 m6A修饰在70年代就发现了，是可以发生在mRNA、lncRNA等RNA的腺嘌呤（A）上的甲基化修饰，在哺乳动物中，发生 m6A修饰的腺嘌呤A比例为0.1–0.4%，算起来每条mRNA只有3-5个m6A甲基化位点。 而U-tail是发生在. RNA的尿嘧啶修饰，通常与RNA的降解过程有关。 哺乳动物和酵母中的m6A位 …

There may be no better all-around worm on the market today than the U-Tale, the perfect mid-size body for the widest variety of conditions, paired with a flapping curly tail which forms the letter “U.” It’s a proven fish catcher anywhere that bass swim – has been for generations and will continue to be so for the foreseeable future.

2014年8月28日 · This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m 6 A) and uridylation (U-tail). RNAs undergo chemical modifications that can affect their activity, localization, and stability (Machnicka et al., 2013), which is conceptually analogous to the modifications of DNA and protein.

2010年6月14日 · The U Tail is another versatile worm. Beefey Body, and a big flowing tail create plenty of action. Attracts a lot of attention, with good water displacement and a great action. Zoom uses a Salt mixture in their baits that makes a fish hold …

2024年2月6日 · Constructed with a thin, ribbed body, the Zoom U Tail features a U-shaped backside that flaps and flickers with minimal movement. Possibly one of the best all-around worms on the market, the Zoom U Tail is applicable to a wide-range of finesse tactics, like shakey heads, Texas-rigs, and split shots.

2018年9月21日 · Two recent studies reveal new roles of uridylation in immune defense against viruses and retrotransposons. Tailing (3′-terminal addition of untemplated nucleotides) occurs on virtually all types of...

2014年8月28日 · Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m (6)A) and uridylation (U-tail). Copyright © 2014 Elsevier Inc. All rights reserved.

8月28日出版的Cell中，首尔大学的研究者发布综述，介绍了N6-甲基腺苷化修饰 (N6-methyladenosine, m 6 A)，以及尿苷化修饰 (uridylation，U-tail)这两种最常见RNA修饰方式的分子机制和生物学功能。 m 6 A这种修饰方式是康奈尔大学维尔医学院的研究人员在2012年发现的，当时研究人员发现，在超过20%的人群中，超过5000种不同的mRNA的腺嘌呤的碱基上会被添加一个甲基 (methyl group)，形成m 6 A修饰。 而这些mRNA中很多是人类疾病相关的基因转录产生 …

Catch more bass with the Zoom U-Tail 6" Worm Baits 20-Pack. This worm has a U-shaped tail and is super soft so bass think it's the real thing. The worm is salt impregnated to attract bass and keep them holding on for hook sets.

Nat Struct Mol Biol. 2018 Oct;25 (10):903-905. doi: 10.1038/s41594-018-0139-0. 1 Center for RNA Research, Institute for Basic Science, Seoul, Korea.