2023年4月20日 · Pro-tumor N2 neutrophils play critical roles in tumor angiogenesis, metastasis and immunosuppression, but therapeutic targeting of this cell type has been challenging.

2019年11月22日 · We developed an in vitro, functional model of clonal cooperation using U87MG glioblastoma cells, which isolates fundamental clonal interactions. In this model pre-labeled clones are co-cultured...

报道,该细胞可在裸鼠体内成瘤。U-87 MG 细胞( 也称为U87 细胞)起 源于中枢神经系统的恶性肿瘤,表现出胶质母细胞瘤的许多标志性特征,包 括快速增殖、高 侵入�. 、显著的遗传和表型异质性等。该 细胞是神经生物学、免疫肿瘤学和癌症研究中最广泛使用的细胞模型之一, 也是研究脑部肿瘤的分子�. 胞机制和治疗策略. 95%, 二氧化碳5%; 温度:37 摄�. n . 69 ce. l lines derived from human tumo. enetically aberrant human cancer cell. �. 干冰是否完全挥发等异常现象。如 发 …

2019年1月14日 · Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D...

2010年1月29日 · The systematic, thorough, and accurate mutational analysis of the U87MG genome comprehensively identifies different classes of genetic mutations including single-nucleotide variations (SNVs), insertions/deletions (indels), and translocations. We found 2,384,470 SNVs, 191,743 small indels, and 1,314 large structural variations.

2024年2月27日 · U87MG cells, as expected from immunoflurescence analysis (Additional file 1: Fig. S2B-C), also showed efficient anti-CD44 antibody internalization (Additional file 1: Fig. S2D), and sensitivity to anti-CD44 ADC treatment (Additional file 1: Fig. S2E-F). Together, we provide proof-of-concept for the TS-MAP approach by revealing CD44 as an ...

2023年8月24日 · 人脑胶质瘤细胞系u87mg是一个常用的研究模型，被广泛应用于胶质瘤的基础研究和药物筛选。 U87MG细胞系是从一位人类胶质母细胞瘤病人的手术样本中建立的。

2023年9月20日 · U87MG细胞系起源于一位女性患者的星形胶质细胞，其基因组包含了多个重要的突变和异常，例如EGFR扩增、PTEN缺失、TP53突变等。 这些突变在很大程度上推动了胶质瘤的发生和发展。 U87MG细胞系的倍增时间短，生长迅速，可在体外培养条件下迅速增殖。 此外，U87MG细胞系对多种化疗药物和放射治疗均具有敏感性，这为其在药物筛选和抗癌研究中的应用提供了可能。 U87MG细胞系已被广泛应用于神经科学、肿瘤学、药理学等多个领域。 在胶质 …

U87 GBM cells with stemness features demonstrate increased cytotoxicity to NK cells in association with altered NKG2D ligand expression of NK cell activating receptor. Applying immune modulation to GBM treatment may be a promising adjuvant therapy in …

2016年8月31日 · We have examined these questions using genetic profiling and transcriptome analysis in human glioma cell lines. We find that the DNA profile of the widely used glioma cell line U87MG is different from that of the original cells and that it is likely to be a bona fide human glioblastoma cell line of unknown origin.