2023年4月3日 · Unfractionated heparin (UFH) binds to antithrombin III (AT-III), which enhances antithrombin's inhibition of several coagulation factors – especially factor Xa and factor IIa (thrombin). Low Molecular-Weight Heparin (LMWH) is a heterogeneous collection of heparin molecules with a lower average molecular weight compared to unfractionated heparin.

This topic will review the general principles underlying the therapeutic use of unfractionated and LMW heparins including dosing, monitoring, and reversal of anticoagulation, as well as danaparoid (not available in the United States).

Venous thromboembolism (VTE) is a prevalent and serious condition. Its medical treatment requires anticoagulation, usually with either unfractionated or low molecular weight heparin (LMWH). Administration of unfractionated heparin (UFH) is usually intravenous (IV) but can be subcutaneous as well.

2024年6月6日 · One of the main differences between the two types of heparins is how you get them. You get UFH through an IV, usually at a hospital, but you can inject yourself with LMWH at home. UFH works right...

Unfractionated Heparin (UFH) is a fast-acting blood thinner that works together with antithrombin, a natural protein in the body, to block clot formation. Specifically, UFH binds to antithrombin and enhances its ability to inhibit two of the body’s most potent clotting factors – factor Xa and factor IIa – usually within minutes.

2001年7月1日 · Heparin is a sulfated polysaccharide with a molecular weight range of 3000 to 30 000 Da (mean, 15 000 Da). It produces its major anticoagulant effect by inactivating thrombin and activated factor X (factor Xa) through an antithrombin (AT)-dependent mechanism.

2007年7月13日 · UFH produces its major anticoagulant effect by inactivating thrombin and activated factor X (factor Xa) through an antithrombin-dependent mechanism. UFH binds to antithrombin through a high-affinity pentasaccharide, leading to a conformational change.