2001年7月1日 · Reduced binding to plasma proteins and cells is responsible for the more predictable dose-response relationship of LMWH, longer plasma half-life (compared with …

2023年4月3日 · Unfractionated heparin (UFH) binds to antithrombin III (AT-III), which enhances antithrombin's inhibition of several coagulation factors – especially factor Xa and factor IIa …

saccharide units, UFH has an anti–factor Xa to anti–factor IIa ratio of 1:1. In contrast, commercial LMWHs have anti– factor Xa to anti–factor IIa ratios between 2:1 and 4:1, depending on their …

UFH blocks thrombin-induced activation of factors V and VII, enhances tissue factor pathway inhibitor (TFPI) release by vascular endothelial cells reducing the procoagulant activity of the …

Heparin: anticoagulant; unfractionated heparin (UFH) is a sulfated polysaccharide with a molecular weight range of 3 to 30 kDa

Unfractionated heparin (UFH) was the first anticoagulant drug, discovered in 1916 by a medical student at Johns Hopkins University, Jay McLean, while studying the putative prothrombotic …

Unfractionated heparin (UFH) acts as an anticoagulant by forming a complex with antithrombin (AT) catalysing the inhibition of several activated blood coagulation factors: thrombin (factor …

2021年7月1日 · Unfractionated heparin (UFH), with a sulfated glycosaminoglycan with an average molecular weight of 15–19 kDa, is commonly used as a synonym for heparin in clinical …

2018年4月17日 · Unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) are highly utilized throughout inpatient and ambulatory care settings for many indications, …

Patients with chronic kidney disease (CKD) treated with conventional anticoagulant agents [vitamin K antagonist (VKA), low-molecular weight heparin (LMWH) or unfractionated heparin …