Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule.

Glucuronidation represents a major pathway that enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. UDP-glucuronosyltransferases (UGTs, or UDPGTs; EC 2.4.1.17) catalyze the addition of the glycosyl group from a nucleotide sugar to a small hydrophobic molecule (aglycone).

For naming each gene, we propose that the root symbol UGT for human (Ugt for mouse), representing "UDP glucuronosyltransferase," be followed by an Arabic number denoting the family, a letter designating the subfamily, and an Arabic numeral representing the individual gene within the family or subfamily (hyphen before the Arabic number for mouse ...

For naming each gene, it is recommended that the root symbol UGT for human (Ugt for mouse and Drosophila), denoting 'UDP glycosyltransferase,' be followed by an Arabic number representing the family, a letter designating the subfamily, and an Arabic numeral denoting the individual gene within the family or subfamily, e.g. 'human UGT2B4' and ...

2013年6月1日 · Human UDP-glucuronosyltransferase (UGT) enzymes predominantly catalyse a reaction referred to as ‘glucuronidation’. This reaction involves the covalent linkage (conjugation) of glucuronic acid, derived from the cofactor UDP-glucuronic acid (UDPGlcUA), to a substrate bearing a suitable functional group.

UGT酶（尿苷二磷酸葡萄糖醛酸转移酶） 占比第二，是人体Ⅱ相代谢中最重要的酶之一，参与着很多药物的代谢清除过程。 UGT酶利用葡萄糖醛酸为糖基供体，广泛催化内源性（如胆红素、脂肪酸、甾体类激素、食物中的化合物、药物、环境污染物等）和外源性化学物质发生结合反应，通常结合反应后的化合物更具水溶性，易于排出体外，从而起到解毒的作用。 但是这类结合反应存在一种 特殊情况，即 结合位点发生在羧基上，形成潜在的毒性代谢物 ── 酰基葡萄糖醛酸代谢产 …

2024年12月25日 · UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1) is a Protein Coding gene. Diseases associated with UGT1A1 include Crigler-Najjar Syndrome, Type I and Crigler-Najjar Syndrome, Type Ii. Among its related pathways are Drug ADME and Metapathway biotransformation Phase I and II.

尿苷二磷酸葡萄糖醛酸转移酶(ugt)是人体重要的ii相代谢酶,具有代谢药物和内源性物质的重要作用，其广泛分布于肝、肾、呼吸道、肺、胃、小肠、结肠等多种组织器官中。

2002年12月27日 · UDP-Glucuronosyltransferase (UGT), the microsomal enzyme responsible for glucuronidation reactions, exists as a superfamily of enzymes. Genetic polymorphism has been described for 6 of the 16 functional human UGT genes characterised to date, namely UGT 1A1, 1A6, 1A7, 2B4, 2B7 and 2B15.

The uridine diphosphate glucuronosyltransferase (UGT) enzymes are a superfamily of enzymes responsible for the glucuronidation of target substrates. The transfer of glucuronic acid renders xenobiotics and other endogenous compounds water soluble, allowing for …