2024年12月25日 · UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1) is a Protein Coding gene. Diseases associated with UHRF1 include Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome and Colorectal Cancer. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. [5][6] This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases.

2024年12月26日 · uhrf1的主要功能是调控dna甲基化和组蛋白修饰，这两个过程对基因的表达调控至关重要。 具体来说，UHRF1通过识别和结合甲基化的DNA和特定的组蛋白修饰，帮助维持基因的沉默状态。

UHRF1 是联系DNA甲基化与组蛋白甲基化的关键蛋白。 我们发现其PHD结构域特异性识别组蛋白H3的第二位精氨酸（H3R2） (Cell Res, 2021)，其TTD结构域和PHD结构域共同作用，使UHRF1特异性识别组蛋白H3K9me3 (JBC, 2013)....

2025年2月9日 · UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma. Interfering with the Expression of Ubiquitin-Like with PHD and Ring Finger Domains 1 Can Inhibit the Invasion of Human Renal Cell Carcinoma. UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.

2013年3月5日 · Epigenetic inheritance of DNA methylation in mammals requires a multifunctional protein UHRF1, which is believed to recruit DNMT1 to DNA replication forks through a unique hemi-methylated...

UHRF1 is a master regulator of epigenome as it coordinates DNA methylation and histone modifications. Compelling evidence suggests a strong link between UHRF1 overexpression and tumorigenesis, substantiating its ability to act as a potential biomarker for …

2025年1月13日 · 近日，中国科学院广州生物医药与健康研究院与美国约翰霍普金斯大学合作在 Nature Communications 杂志发表了题为 Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy 的研究成果。 该研究在对UHRF1结构域-功能研究基础上（Cancer Cell, 2019），揭示了多能性调节蛋白STELLA对UHRF1功能抑制的物种特异性与分子机制，进而发展了基于mRNA的UHRF1抑制剂，可有效逆转DNA甲基化异常并发挥抗实体瘤活性。

摘要： UHRF1（ubiquitin-like with PHD and Ring finger domains 1）是一种维持DNA甲基化修饰的表观遗传调控因子，在胚胎发育和肿瘤发生发展及预后中发挥重要作用。研究鉴定了受UHRF1调控的差异表达基因，并对基因参与的细胞功能、代谢途径和疾病相关通路进行分析。

2024年4月5日 · DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA...