The network of Innovation Hubs for Gene Therapies is a new UK initiative designed to advance the clinical development of new genetic treatments through the production of GMP (Good Manufacturing Practice) viral vectors, alongside translational support and regulatory advice.

2022年11月16日 · Through horizon scanning we identified the need for AAV reference materials to support future standardisation of AAV-based gene therapies, which will increase patient confidence in these...

2021年3月18日 · The innovation hubs will manufacture commonly used vectors including both lentivirus and adeno-associated virus (AAV) that are needed for genetic therapy trials. These hubs will position the UK for significant bioprocessing innovation work with the potential to radically increase yields and reduce productivity barriers in future years.

2019年9月26日 · Adeno-associated virus (AAV) is one of the most actively investigated gene therapy vehicles. Now, under the leadership of Prof Chris Shaw, Associate Director of UK DRI at Kings, the institute will be at the forefront of realising this potential.

2021年2月11日 · An international collaboration of leading groups in gene therapy and vision science have developed an adeno-associated virus (AAV) genome-coupled immunomodulation strategy that helps cloak the AAV virus from unwanted immune responses and offers important insights into ocular inflammation.

Across the UK, Building Regulations and statutory guidance allow for both open soil pipes (stacks) or air admittance valves (Figure 1). Whereas the simplest and probably most familiar solution is an open soil pipe, it needs to terminate at least 900mm above any opening to the building, such as a window or balcony.

2025年2月1日 · Adeno-associated viruses (AAVs) have emerged as a promising gene delivery vehicle for the treatment of diseases. As AAVs are a complex therapeutic modality, new analytical techniques are needed to thoroughly characterize the critical quality attributes (CQAs) to support drug development.

The BPF Pipes Group has just launched new guidance on domestic air admittance valves (AAV) for those working within the plumbing sector in the UK. The document provides clear advice on how to position air admittance valves correctly, as well as highlighting the different regulations currently in place across England, Wales, Scotland and ...

2024年1月2日 · Air admittance valves (AAVs) are installed directly on to the soil stack without the need for a hole to be made in the property roof, reducing the amount of pipework required and the costs of making good the roof, and minimising risks of weather damage and water ingress.

AVS is an established EN9100-provider of instrumentation (NASA, CERN, ESA, Airbus, RAFAEL, ISRO, VO…) and counts with over 50 instruments at UKRI-STFC sites in the UK (Harwell, Culham, etc.): micro-mechanisms, plasma devices, CFRP structures, large mechatronic-systems, quantum detectors, thermal and vacuum chambers, particle detectors…