碧云天生产的SUMO Protease (Small Ubiquitin-related Modifier Protease)，是一种重组表达的高度特异性识别SUMO化修饰或SUMO结构域，并水解SUMO羧基端(C端) x-Gly-Gly-x肽段中Gly-Gly后的肽键，从而去除SUMO化修饰或者去除SUMO融合表达蛋白中SUMO结构域的蛋白酶。

SUMO Protease, also known as Ulp, is a recombinant fragment of ULP1 (Ubl-specific protease 1) from Saccharomyces cerevisiae. It is highly specific for the SUMO protein fusion, recognizing the tertiary structure of SUMO rather than an amino acid

2023年11月1日 · Ulp1 is a protease which is naturally present in yeast and specifically cleaves Ubl proteins (ubiquitin-like proteins) such as SUMO1 and Smt3 from other proteins [4]. Ulp1 is a valuable tool in molecular biology for cleaving SUMO-tags from recombinant proteins.

sumo 蛋白酶（又称 ulp 蛋白酶）是一种高活性的半胱氨酸蛋白酶，识别完整的sumo蛋白序列，并依赖于正确的蛋白构象，因此酶切反应具有很高的特异性。

SUMO（小分子泛素修饰）蛋白酶1（Ulp1，来自酿酒酵母的Ubl特异性蛋白酶1）是一种高活性的半胱氨酸蛋白酶。 Ulp1由于可以识别类泛素（UBL）蛋白SUMO（Smt3）的三级结构，而不是其氨基酸序列，因此具有高度特异性。

The Champion pET SUMO Expression System produces the highest levels of soluble protein in E. coli. It utilizes a small ubiquitin-related modifier (SUMO) fusion, belonging to the growing family of ubiquitin-related proteins, to enhance t

SUMO proteases of the SENP/Ulp family are master regulators of both sumoylation and desumoylation and regulate SUMO homeostasis in eukaryotic cells. SUMO conjugates rapidly increase in response to cellular stress, including nutrient starvation, hypoxia, osmotic stress, DNA damage, heat shock, and other proteotoxic stressors.

The Ulp1 protease catalyzes two essential functions in the SUMO pathway: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins. Selective reduction of the proteolytic reaction produced a covalent thiohemiacetal transition state complex between a Ulp1 C-terminal fragment and its cellular ...

2012年11月23日 · Small ubiquitin-related modifier (SUMO) proteases control cellular mechanisms, including transcription, cell division and ribosome biogenesis. The function of SUMO proteases...

SUMO Protease, also known as Ulp, is a recombinant fragment of ULP1 (Ubl-specific protease 1) from Saccharomyces cerevisiae. It is highly specific for the SUMO protein fusion, recognizing the tertiary structure of SUMO rather than an amino acid sequence.