UNC13A plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool.

This literature review explores the pivotal roles of the Uncoordinated-13 (UNC13) protein family, encompassing UNC13A, UNC13B, UNC13C, and UNC13D, in the pathogenesis of various human diseases. These proteins, which are evolutionarily conserved and ...

1999年11月1日 · We analyzed the synaptic physiology of unc-13 mutants in the nematode C. elegans. Mutants of unc-13 had normal nervous system architecture, and the densities of synapses and postsynaptic...

1999年11月1日 · UNC-13 was first identified in the nematode Caenorhabditis elegans by the classical genetic screening efforts of Brenner 7. He found that mutations in a number of genes, including unc-13,...

2024年12月25日 · UNC13A (Unc-13 Homolog A) is a Protein Coding gene. Diseases associated with UNC13A include Amyotrophic Lateral Sclerosis 21 and Amyotrophic Lateral Sclerosis 18. Among its related pathways are 16p11.2 proximal deletion syndrome and …

1999年11月1日 · The UNC-13 protein family has been suggested to be critical for synaptic vesicle dynamics based on its interactions with Syntaxin, Munc-18 and Doc 2α.

2019年8月1日 · Unc13 functions together with SM proteins to guide proper SNARE assembly. Release site construction and calcium channel coupling are both controlled by Unc13. Unc13 endows synapses with several forms of short-term plasticity.

unc-13 同系物 C： 预测启用钙调蛋白结合活性和 syntaxin-1 结合活性。 预计参与多个过程，包括谷氨酸能突触传递；调节胞吐作用；和突触小泡成熟。 预测位于突触前活动区。

Current models propose that UNC-13 primes vesicles by stabilizing Syntaxin's “open” conformation by directly interacting with its amino-terminal regulatory domain [6–8]. However, the functional significance of the UNC-13/Syntaxin interaction has not been tested directly.

We analyzed the synaptic physiology of unc-13 mutants in the nematode C. elegans. Mutants of unc-13 had normal nervous system architecture, and the densities of synapses and postsynaptic receptors were normal at the neuromuscular junction. However, the number of synaptic vesicles at neuromuscular ju …