Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon endoplasmic reticulum (ER) stress conditions. It is known to be ...

The activation of the UPR involves three signaling pathways, IRE1, PERK and ATF6, which all play vital roles in returning protein homeostasis to levels seen in non-stressed cells. IRE1 is the best studied of the three pathways, as it is the only pathway present in …

2024年4月18日 · In this study, we demonstrate cross talk between the IRE1 and PERK branches of the UPR, wherein IRE1 via XBP1s signaling helps to sustain PERK expression during prolonged ER stress.

Unfolded Protein Response (UPR)由内质网（ER）中的未折叠蛋白（unfolded or misfolded），在基因表达的层面上提高内质网蛋白折叠的能力（protein-folding capacity）。 归根结底就是通过一系列信号来翻译生成新的转录调控蛋白。 由IRE1 kinase介导的UPR具体的调控过程如下：内质网中的错误折叠蛋白提示需要更多的内质网分子伴侣蛋白（chaperone），因此它们会结合并激活一种跨膜激酶（transmembrane kinase）。 活化的跨膜激酶反映的是核糖核酸内切 …

2020年7月20日 · Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse...

Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) promote cell survival by reducing misfolded protein levels. UPR signaling also promotes apoptotic cell death if ER stress is not alleviated.

2023年4月19日 · Accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen causes ER stress, which triggers the unfolded protein response (UPR) to restore protein homeostasis. So far, three UPR sensors have been identified, including IRE1, PERK, and ATF6.

2021年1月15日 · One of the prime UPR signaling sensors is Inositol-requiring enzyme 1 (IRE1); an ER membrane embedded protein with dual enzyme activities, kinase and endoribonuclease. The ribonuclease activity of IRE1 results in Xbp1 splicing in mammals or Hac1 splicing in yeast.

Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs.

Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1α is an ER-located kinase and endoribonuclease that operates as a major ER stress transducer, mediating the establishment of adaptive and pro-apoptotic programs.