This study was conducted to explore the role of UVB on benzanthrone (BA)-induced skin inflammation and its mechanism/s. SKH-1 hairless mice were topically exposed with BA (25 and 50 mg/kg b.wt) either alone or along with UVB (50 mJ/cm(2)) for 24 h and estimation of ROS, histopathological analysis, m …

2014年6月26日 · Our data showed that E-AP-SM2001 decreased UVB-increased superoxide anion and MPO activity but also dermis inflammatory cell infiltration. Furthermore, E-AP-SM2001 inhibited expression of NADPH oxidase subunit gp91phox, Nox2. These effects of E-AP-SM2001 are likely responsible for the inhibition of neutrophil recruitment and activity 47, 56.

2024年8月15日 · UVB radiation induces inflammatory and oxidative stress responses, contributing to skin damage, yet the underlying mechanisms are not fully understood. N-Myc downstream-regulated gene 2 (NDRG2), an emerging stress-associated gene, remains unexplored in UVB-induced skin injury.

此外，uvb 攻击的ndrg2-/− 小鼠表现出显着升高的促炎细胞因子、髓过氧化物酶 (mpo)、基质金属蛋白酶 8 (mmp8) 和降低的抗氧化剂表达。 rna测序鉴定出1091个显着差异表达的基因，这些基因富含炎症、免疫反应和氧化应激途径。

2025年1月26日 · UVB irradiation induces diverse modalities of regulatory cell death in keratinocytes. Recently, the pattern of coexistence of pyroptosis, apoptosis, and necroptosis has been termed PANoptosis;...

2024年8月15日 · Furthermore, UVB-challenged Ndrg2−/− mice displayed significantly elevated pro-inflammatory cytokines, myeloperoxidase (MPO), matrix metalloproteinase-8 (MMP8), and reduced antioxidant expression. RNA sequencing identified 1091 significantly differentially expressed genes enriched in inflammation, immune response, and oxidative stress pathways.

2022年10月1日 · This study demonstrates that GSDME plays a restrictive role in UVB-induced skin damage through inhibiting excessive recruitment and activation of neutrophils in the immune microenvironment in...

2006年7月3日 · The UVB irradiation (0.31-3.69 J/cm(2)) induced a dose-dependent increase in the myeloperoxidase (MPO) activity (4-2708%) and depletion of reduced glutathione (GSH) (22-68%) in the skin of hairless mice after 6h.

2020年4月24日 · The current data indicated that juglanin administration to mice with UVB-irradiation caused a decrease in MPO activities, further confirming the effects of juglanin on inflammation inhibition. The skin exposure to UVB has a close association with oxidative stress, which is associated with anti-oxidants and oxidants occurring in tissues ( 42 ).

2021年4月1日 · Topical metformin treatment effectively attenuated UVB-induced infiltration of MPO-positive neutrophilic granulocytes and F4/80-positive macrophages (Fig. 6 a and b). Moreover, the results of qRT-PCR confirmed that mRNA levels of IL-1β and TNF-α in skin of UVB-irradiated mice were significantly alleviated by topical metformin treatment ( Fig ...