2024年12月25日 · UVRAG (UV Radiation Resistance Associated) is a Protein Coding gene. Diseases associated with UVRAG include Xeroderma Pigmentosum Group C and Cholecystolithiasis . Among its related pathways are Early SARS-CoV-2 Infection Events and Infectious disease .

UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene. [5] [6] This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain.

UVRAG is one of the key players of autophagy, but its role in vivo remained puzzling. Our recent study utilized a mouse model with inducible expression of a cancer-derived frameshift (FS) mutation in UVRAG that dominant-negatively inhibits wild-type UVRAG, resulting in impaired stimulus-induced autophagy.

UVRAG (UV radiation resistance associated) is an important regulator of mammalian macroautophagy/autophagy by interacting with BECN1, PIK3C3, and RUBCN. Phosphorylation of UVRAG by MTORC1 negatively regulates autophagosome …

UVRAG is a regulator of CRL4 (DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition. Under-expression of UVRAG is associated with colorectal cancer. UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis.

UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, ...

2023年11月6日 · 该研究发现，在哺乳动物细胞中，抗紫外线辐射相关基因UVRAG能有效增强内质网自噬起始点(ER-phagy sites, ERPHS)组装，促进内质网自噬发生。...

该基因补充了着色性干皮病 C 组细胞的紫外线敏感性，并编码具有 C2 结构域的蛋白质。 该蛋白激活 Beclin1-PI (3) KC3 复合物，促进自噬并抑制人结肠癌细胞的增殖和致瘤性。 涉及该基因的染色体畸变与左右轴畸形有关，并且该基因的突变与结肠癌有关。 [RefSeq 提供，2008 年 7 月] This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain.

Our study identified the multifunctional protein UVRAG (UV radiation resistance associated gene) as a novel regulator of reticulophagy. UVRAG interacts with sheet and tubular reticulophagy receptors, regulates the oligomerization of receptors and facilitates their interaction with LC3/GABARAP, critical for ER fragmentation and autophagosome ...

uvrag 是自噬的关键参与者之一，但其在体内的作用仍然令人困惑。 我们最近的研究利用了 UVRAG 中可诱导表达癌源移码 (FS) 突变的小鼠模型，该突变显性负抑制野生型 UVRAG，导致刺激诱导的自噬受损。