泛素结合酶H3 (UbcH3)，也被称为Cell Division Cycle 34 (Cdc34)，是泛素结合酶 (E2)家族的成员。 UbcH3的预测分子量为26 kDa。 人类蛋白与小鼠和大鼠同源蛋白有98%的氨基酸 (aa)序列同源性。 除了E2催化核心结构域外，UbcH3还有两个泛素结合位点UBS1 (来自aa 205-215)和UBS2 (来自aa 216-225)，以及一个c端酸性尾部结构域。 在人类细胞中，UbcH3是有效的细胞周期进程所必需的。 UbcH3与SCF (Fbw7)和SCF (Skp2)泛素连接酶 (e3)相互作用，分别靶向关键的细胞周 …

1994年8月15日 · The human UbcH 1 significantly increases the resistance of cells to UV radiation. The major UV-induced DNA lesions are cyclobutane pyrimidine dimers and 6-4 photoproducts, which are preferentially repaired by a multistep repair process called nucleotide excision repair (NER) (recently reviewed in [25,26]).

The Units of Battle Hugo Chávez (UBCh) is a collection of organizations with multiple members of PSUV involved that has both military and political characteristics. [1] The UBCh originated as a group to defend the Bolivarian Revolution and support PSUV through electoral processes in …

2006年3月17日 · Protein ubiquitination is a powerful regulatory modification that influences nearly every aspect of eukaryotic cell biology. The general pathway for ubiquitin (Ub) modification requires the sequential activities of a Ub-activating enzyme (E1), a Ub transfer enzyme (E2), and a Ub ligase (E3).

2022年3月10日 · These results indicated that inhibiting UbcH5c is a novel and effective strategy for treating pancreatic cancer and DHPO represents a new class of UbcH5c inhibitor and may be further developed as an anti-pancreatic cancer therapeutic agent.

Recombinant Human UbcH5a/UBE2D1 is a member of the Ubiquitin-conjugating (E2) enzyme family that receives Ubiquitin from a Ubiquitin-activating (E1) enzyme and subsequently interacts with a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application.

UBE2H抗体（G-2）是一种IgG1 κ小鼠单克隆UBE2H抗体（也称为UBE2H抗体），它通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的UBE2H蛋白。 UBE2H抗体（G-2）既可以作为非偶联抗UBE2H抗体形式提供，也可以作为多种偶联形式的抗UBE2H抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。 UBE2H（泛素结合酶E2H），也被称为UBC8、UBCH、UBCH2或E2-20K，是一种由183个氨基酸组成的蛋白质，参与泛素介导的蛋白质降解。 泛素 …

2024年12月10日 · The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

UBCH / UBE2H ubiquitin-conjugating enzyme E2H. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.