2024年12月25日 · UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Alternating Hemiplegia Of Childhood 2 and Long Qt Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System.

2024年1月31日 · We recently discovered that UBR4, an E3 ligase known for its role in the N-end rule pathway 9, helps degrade aggregation-prone nascent polypeptides 10. As mutations in UBR4 cause ataxia and...

2023年11月29日 · Structural analysis revealed that the UBR box of UBR4 differs from other UBR boxes in the N-degron binding sites. It recognizes type-2 N-terminal amino acids containing an aromatic ring and...

由该基因编码的蛋白质是一种 E3 泛素蛋白连接酶，它与细胞核中的视网膜母细胞瘤相关蛋白和细胞质中的钙结合钙调蛋白相互作用。 编码的蛋白质似乎是细胞质中的细胞骨架成分和细胞核中染色质支架的一部分。 此外，该蛋白是人乳头瘤病毒 16 型 E7 癌蛋白的靶标。 [RefSeq 提供，2010 年 8 月] The protein encoded by this gene is an E3 ubiquitin-protein Ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound Calmodulin in the …

2024年1月5日 · UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin (Ub)...

E3 ubiquitin-protein ligase UBR4 is an enzyme that in humans is encoded by the UBR4 gene. [5] [6] [7] [8]

2024年3月12日 · ubr4是e3连接酶的一种。研究者发现，ubr4的突变会导致共济失调和早发性痴呆症的发生，而ubr4保障特定通路的质量控制功能则能够确保细胞的稳态。 当线粒体功能受损导致应激反应发生时，ubr4便显得尤为重要。

2025年2月9日 · The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes. Pathogenic mutation in UBR4 gene is associated with Episodic Ataxia. Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from podocytes.

2024年12月18日 · Our cryo-EM analysis of UBR4 in complex with its cofactors KCMF1 and CALM1 reveals a massive 1.3 MDa ring structure, featuring a central substrate-binding arena and flexibly attached catalytic units. Structural data illustrate how UBR4 binds substrate and extends K48-specific ubiquitin chains.

2013年2月19日 · UBR4 of the YS endoderm is associated with a tissue-specific autophagic pathway that mediates bulk lysosomal proteolysis of endocytosed maternal proteins into amino acids. In cultured cells, UBR4 subpopulation is degraded by autophagy through its starvation-induced association with cellular cargoes destined to autophagic double membrane structures.