UBR4 Gene - GeneCards | UBR4 Protein | UBR4 Antibody
Dec 25, 2024 · UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Alternating Hemiplegia Of Childhood 2 and …
Stress response silencing by an E3 ligase mutated in ... - Nature
Jan 31, 2024 · We recently discovered that UBR4, an E3 ligase known for its role in the N-end rule pathway 9, helps degrade aggregation-prone nascent polypeptides 10. As mutations in …
Insights into the recognition mechanism in the UBR box of UBR4 …
Nov 29, 2023 · Structural analysis revealed that the UBR box of UBR4 differs from other UBR boxes in the N-degron binding sites. It recognizes type-2 N-terminal amino acids containing an …
泛素蛋白连接酶 E3 组分 n-识别素 4（UBR4）基因 | MCE
由该基因编码的蛋白质是一种 E3 泛素蛋白连接酶，它与细胞核中的视网膜母细胞瘤相关蛋白和细胞质中的钙结合钙调蛋白相互作用。 编码的蛋白质似乎是细胞质中的细胞骨架成分和细胞核 …
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
Jan 5, 2024 · UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that …
UBR4 - Wikipedia
E3 ubiquitin-protein ligase UBR4 is an enzyme that in humans is encoded by the UBR4 gene. [5] [6] [7] [8]
Nature：压力过大的脑细胞才是阿尔茨海默病等疾病的原因？_澎 …
Mar 12, 2024 · ubr4是e3连接酶的一种。研究者发现，ubr4的突变会导致共济失调和早发性痴呆症的发生，而ubr4保障特定通路的质量控制功能则能够确保细胞的稳态。 当线粒体功能受损导 …
UBR4 ubiquitin protein ligase E3 component n-recognin 4
Feb 9, 2025 · The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes. Pathogenic mutation in UBR4 gene is …
Dec 18, 2024 · Our cryo-EM analysis of UBR4 in complex with its cofactors KCMF1 and CALM1 reveals a massive 1.3 MDa ring structure, featuring a central substrate-binding arena and …
UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule ... - PNAS
Feb 19, 2013 · UBR4 of the YS endoderm is associated with a tissue-specific autophagic pathway that mediates bulk lysosomal proteolysis of endocytosed maternal proteins into amino acids. In …