2024年1月31日 · We recently discovered that UBR4, an E3 ligase known for its role in the N-end rule pathway 9, helps degrade aggregation-prone nascent polypeptides 10. As mutations in UBR4 cause ataxia and...

2024年1月5日 · UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin (Ub)...

2024年12月25日 · UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Alternating Hemiplegia Of Childhood 2 and Long Qt Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System.

2023年3月11日 · Biochemical assays and animal studies demonstrated that in LPCs, the E2-conjugating enzyme UBE2L6 depletes EZH2 protein in cooperation with UBR4, an E3 ligase, via ubiquitination at EZH2’s K381...

2021年8月3日 · UBR box E3 ligases, also called N-recognins, are integral components of the N-degron pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they bind destabilizing N-terminal residues, termed N-degrons. Understanding the molecular bases of their substrate recognition and the bio …

由该基因编码的蛋白质是一种 E3 泛素蛋白连接酶，它与细胞核中的视网膜母细胞瘤相关蛋白和细胞质中的钙结合钙调蛋白相互作用。 编码的蛋白质似乎是细胞质中的细胞骨架成分和细胞核中染色质支架的一部分。 此外，该蛋白是人乳头瘤病毒 16 型 E7 癌蛋白的靶标。 [RefSeq 提供，2010 年 8 月] The protein encoded by this gene is an E3 ubiquitin-protein Ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound Calmodulin in the …

2017年1月1日 · The name UBR4 refers to its function as an E3 ubiquitin (Ub) ligase in the N-end rule proteolytic pathway, whereas the alternative name of p600 reflects the ~600 kDa size of this protein. Its role in the N-end rule pathway was revealed in a study that established significant retention of the pathway’s activity in fibroblasts that lacked the ...

2025年2月9日 · The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus.

2023年11月29日 · Structural analysis revealed that the UBR box of UBR4 differs from other UBR boxes in the N-degron binding sites. It recognizes type-2 N-terminal amino acids containing an aromatic ring and...

2024年12月18日 · Ubiquitin E3 ligases (E3s) interact with substrate proteins and provide specificity to the pathway. A small subset of E3s bind to specific exposed N-termini (N-degrons) and promote the ubiquitination of the bound protein. Collectively these E3s, and other N-degron binding proteins, are known as N-recognins.