2024年12月25日 · UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Alternating Hemiplegia Of Childhood 2 and Long Qt Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System.

2023年11月29日 · Our findings suggest that the UBR box of UBR4 recognizes type-1 N-terminal arginine and type-2 N-terminal amino acids containing an aromatic ring, such as tyrosine, tryptophan, and phenylalanine...

2025年1月5日 · HIV-1 Pol is identified to have a physical interaction with ubiquitin protein ligase E3 component n-recognin 4 (UBR4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses

2024年1月31日 · We recently discovered that UBR4, an E3 ligase known for its role in the N-end rule pathway 9, helps degrade aggregation-prone nascent polypeptides 10. As mutations in UBR4 cause ataxia and...

UBR4 knockout mice, in which exon 1 was deleted, died at E11.5-E13.5 associated with defects in embryonic and placental development . When exon 1 was deleted in mice by mating with transgenic mice expressing Cre driven by Sox2 promoter, embryonic growth was arrested leading to death around E12.5-E14.5 with defects in cardiogenesis [ 43 , 44 ].

2013年2月19日 · UBR4 of the YS endoderm is associated with a tissue-specific autophagic pathway that mediates bulk lysosomal proteolysis of endocytosed maternal proteins into amino acids. In cultured cells, UBR4 subpopulation is degraded by autophagy through its starvation-induced association with cellular cargoes destined to autophagic double membrane structures.

2022年3月24日 · To investigate the role of UBR4 in the murine SCN, we conditionally ablated the Ubr4 gene in GABAergic neurons by breeding Ubr4 fl/fl mice, which possess loxP sites flanking exon 1, with...

2017年1月1日 · The human p600/ubr4 gene is 15,906 bp long and is located on chromosome 1p36.13. It contains 106 exons that encode for the full-length, 5183 amino acid (aa) polypeptide.

For deletions/duplications extending beyond the reference transcript resp. {0}/ {2} is used to replace del/dup. Extent of the deletion/duplication should be specified using the genomic description (g.). "-" indicates the variant described on genomic level does not affect the coding DNA reference sequence.

The N-recognin functions of UBR1, UBR2, UBR4, and UBR5 have been well characterized; however, the functions of UBR3, UBR6, and UBR7 remain largely unknown. This section discusses the role of these UBR N-recognins in signaling pathways, including G-protein signaling, apoptosis, mitochondrial quality control, inflammation, and DNA damage signaling.