UBR5 forms ligand-dependent complexes on chromatin to
2023年7月20日 · Here, we demonstrate the ubiquitin ligase UBR5 drives degradation of multiple agonist-bound NRs, including the retinoic acid receptor alpha (RARA), retinoid x receptor …
E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in …
2024年5月16日 · We found that ubiquitin-protein ligase E3 module N-recognition 5 (UBR5) is a therapeutic target against GEM resistance. UBR5 was markedly upregulated in clinical GEM …
To be (in a transcriptional complex) or not to be (promoting UBR5 ...
2023年8月3日 · Tsai et al.1 in this issue and Mark et al.2 in Cell reveal how the E3 ligase UBR5 mediates broad regulation by selectively targeting agonist-bound nuclear hormone receptors, …
Nature最新报告：抗癌新突破——难成药靶点MYC“有戏了”！
2022年11月19日 · 通过在可以打开和关闭 myc 的细胞系中筛选适合降解剂，确定了具有myc 活性的化合物降解剂gspt1。在 500 多种癌细胞系和80 种异种移植疾病模型中进行筛选时，gspt1 …
Structure of the human UBR5 E3 ubiquitin ligase - Cell Press
The human UBR5 is a single polypeptide chain homology to E6AP C terminus (HECT)-type E3 ubiquitin ligase essential for embryonic development in mammals. Dysregulated UBR5 …
A review: targeting UBR5 domains to mediate emerging roles and ...
2024年8月1日 · As a member of E3 ligase, ubiquitin protein ligase E3 component n-recognin 5 (UBR5) belongs to the HECT E3 ligase and has been reported to be correlated with various …
征服MYC：曙光初现|降解剂|蛋白质|二聚体|细胞|药物|靶向|-健康界
2022年11月25日 · 随后在500多个癌细胞系和80种疾病异种移植模型中筛选出gspt1降解物，证明其具有抗癌潜力。 MRT-2359的I期试验目前正在MYC驱动的肿瘤中进行。 此外，BMS正在急 …
The role of UBR5 in tumor proliferation and oncotherapy
2024年5月15日 · UBR5 paracrine action drives CCL2/CSF-1 infiltration and inhibits macrophage phagocytosis, promoting the growth and metastasis of OC; UBR5 via GOLPH3-Wnt/ β-catenin …
Harnessing UBR5 for targeted protein degradation of key …
2023年11月1日 · Targeted protein degradation (TPD) has opened the door for drugging transcriptional regulators, yet the number of proteins targeted and E3 ligases utilized remain …
UBR5 - GSPT1 Interaction Summary | BioGRID
Using a genetic screen in mouse embryonic stem (ES) cells, we identify mammalian hyperplastic discs protein EDD, a known E3 ubiquitin ligase, as a key component of the miRNA silencing …
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