Insights into the recognition mechanism in the UBR box of UBR4 …
2023年11月29日 · Structural analysis revealed that the UBR box of UBR4 differs from other UBR boxes in the N-degron binding sites. It recognizes type-2 N-terminal amino acids containing an aromatic ring and...
Signaling Pathways Regulated by UBR Box-Containing E3 Ligases
2021年8月3日 · UBR box E3 ligases, also called N-recognins, are integral components of the N-degron pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they bind destabilizing N-terminal residues, termed N-degrons.
泛素蛋白链接酶E3 识别素5,(ubiquitin protein ligase E3 component n-recognin 5, UBR5, 又名EDD1) 具有独特的结构特征,参与了DNA损伤反应、代谢、转录和凋亡的调节,在癌症和发育过程中成为UPS 的关键调节因子。 UBR5在癌症中的作用引起了科研人员的广泛关注。 本文将从UBR5 的结构、泛素化与E3 泛素化连接酶的作用、UBR5在各种癌症中的作用及其作用机制进行综述。 *通讯作者。 文章引用: 王小兵, 伍阅, 李金昊, 龚建平. UBR5 在肿瘤发生发展中作用及其机制 …
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
2024年1月5日 · UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin (Ub) transfer...
UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule ... - PNAS
2013年2月19日 · Our previous studies identified the mammalian N-recognin family consisting of UBR1/E3α, UBR2, UBR4/p600, and UBR5, which recognize destabilizing N-terminal residues through the UBR box. In the current study, we addressed the physiological function of a poorly characterized N-recognin, 570-kDa UBR4, in mammalian development.
Stress response silencing by an E3 ligase mutated in ... - Nature
2024年1月31日 · We recently discovered that UBR4, an E3 ligase known for its role in the N-end rule pathway 9, helps degrade aggregation-prone nascent polypeptides 10. As mutations in UBR4 cause ataxia and...
UBR5 forms ligand-dependent complexes on chromatin to
2023年7月20日 · Here, we demonstrate the ubiquitin ligase UBR5 drives degradation of multiple agonist-bound NRs, including the retinoic acid receptor alpha (RARA), retinoid x receptor alpha (RXRA), glucocorticoid, estrogen, liver-X, progesterone, and vitamin D receptors.
A family of mammalian E3 ubiquitin ligases that contain the UBR …
An affinity assay for proteins that bind to destabilizing N-terminal residues has identified, in addition to UBR1 and UBR2, a huge (570 kDa) mouse protein, termed UBR4, and also the 300-kDa UBR5, a previously characterized mammalian E3 known as EDD/hHYD.
Q5T4S7 - UniProt
Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed ...
UBR4 Gene - GeneCards | UBR4 Protein | UBR4 Antibody
2024年12月25日 · UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Alternating Hemiplegia Of Childhood 2 and Long Qt Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System.