2021年7月10日 · UBXN1 levels were decreased in YTHDF2- and METTL3-overexpressing xenografts and colocalized with increased levels of NF-κB (p65) (Fig. 7D). Fig. 7 YTHDF2 and METTL3 promotes tumor growth and leads to a worse prognosis in an orthotopic xenograft model.

2022年10月22日 · First, EPIC-0412 represses the p-p65 level by upregulating UBXN1 and subsequently inhibiting the MGMT gene activation. Besides, EPIC-0412 upregulates ATF3 expression facilitating the recruitment of the HDAC1 to the MGMT promoter region, forming a complex with p-p65, mediating the deacetylation of H3K27ac, resulting in the MGMT transcriptional ...

2017年2月2日 · Here we demonstrate that over-expression of multiple UBXN family members decreased lentivirus and retrovirus production by several orders-of-magnitude in single cycle assays, at the level of long terminal repeat-driven transcription, and three family members, UBXN1, N9, and N11 blocked the canonical NFκB pathway by binding to Cullin1 (Cul1), inh...

2021年7月10日 · UBXN1 overexpression could attenuate malignant progression and NFKB activation that induced by YTHDF2 overexpression in glioma cells. A CCK-8 assay (proliferation assay) of U87 cells with or ...

2024年12月25日 · UBXN1 (UBX Domain Protein 1) is a Protein Coding gene. Diseases associated with UBXN1 include Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia and 3-Methylcrotonyl-Coa Carboxylase Deficiency.

D-F Kaplan-Meier curves of gliomas with higher (larger than the median expression levels of respective cohorts) expression YTHDF2 stratified by UBXN1 expression in different datasets from ...

2015年4月17日 · UBX domain-containing protein 1 (UBXN1) contains both the N-terminal UBA domain and the C-terminal UBX domain, and it was recently discovered to interfere with RIG-I-mediated antiviral immune response by targeting the mitochondrial antivirus-signaling protein (16).

Our findings confirmed that YTHDF2 promotes the malignant progression of gliomas and revealed important insight into the upstream regulatory mechanism of NF-κB activation via UBXN1 with a primary focus on m 6 A modification. The online version contains supplementary material available at 10.1186/s13045-021-01124-z.

2024年5月21日 · UBXN1 facilitates the growth of human HCC cells and promotes mouse liver tumorigenesis driven by the NRas/c-Myc or c-Myc/shp53 combination. UBXN1 interacts with the inner mitochondrial membrane protein PHB and sustains PHB expression. UBXN1 inhibition triggers mitochondrial damage and liver tumor cell apoptosis.

2024年10月23日 · Ubiquitin regulatory X (UBX) domain-containing protein 6 (UBXN6) is an essential cofactor for the activity of the valosin-containing protein p97, an adenosine triphosphatase associated...