2024年12月25日 · UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a Protein Coding gene. Diseases associated with UCHL1 include Spastic Paraplegia 79B, Autosomal Recessive and Parkinson Disease 5, Autosomal Dominant. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Metabolism of proteins.

Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15, ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme. Neurons from rat brain tissue stained green with antibody to ubiquitin C-terminal hydrolase L1 (UCH-L1) which highlights the …

UCH-L1 is not essential for neuronal development but it is absolutely required for the maintenance of axonal integrity and UCH-L1 dysfunction is implicated in neurodegenerative disease. Here we review the properties of UCH-L1, and how understanding its complex structure can provide new insights into its roles in neuronal function and pathology.

2024年8月1日 · Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an extremely abundant protein in the brain where, remarkably, it is estimated to make up 1–5% of total neuronal protein. Although it comprises only 223 amino acids it has one of the most …

UCHL1 acts as a potential oncogene and affects sensitivity of common anti-tumor drugs in lung adenocarcinoma. UCHL1 promotes proliferation and metastasis in head and neck squamous cell carcinoma and could be a potential therapeutic target. UCHL1 protects against ischemic heart injury via activating HIF-1alpha signal pathway.

该酶是一种硫醇蛋白酶，可水解泛素 C 末端甘氨酸的肽键。 该基因在神经元和弥漫性神经内分泌系统的细胞中特异性表达。 该基因的突变可能与帕金森病有关。 [RefSeq 提供，2009 年 9 月] The protein encoded by this gene belongs to the peptidase C12 family. This Enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

In this study, the use of loss- and gain-of-function approaches revealed a novel role for UCHL1 in regulating cardiac hypertrophy and dysfunction. UCHL1 positively regulates cardiac hypertrophy by attenuating EGFR ubiquitination and degradation.

2024年2月20日 · We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is elevated in tissues and plasma from patients with neuroendocrine carcinomas. Loss of UCHL1 decreases tumor growth and …

泛素c-末端水解酶l1（uchl1）是一种独特的脑特异性去泛素化酶。 uchl1的突变和异常功能与许多神经系统疾病有关。 uchl1活性保护神经元免受缺氧损伤，并且中风诱导的反应性脂质物质与uchl1的半胱氨酸152（c152）的结合使得uchl1去折叠，并破坏其功能。

Ubiquitin C-terminal hydrolase 1 (UCHL1) is an enzyme unique for its multiple activity - both ligase and hydrolase. UCHL1 was first identified as an abundant protein found in the brain and testes, however its expression is not limited to the neuronal compartment. UCHL1 is also highly expressed in ca …