2023年2月12日 · Ursodeoxycholic acid is a medication used to manage and treat cholestatic liver disease. This activity reviews the indications, mechanism of action, and contraindications for UDCA as a valuable agent in managing liver disease.

2024年8月12日 · Ursodeoxycholic acid tablet, also known as UDCA, is a secondary bile acid derived from cholesterol. It is primarily used to treat gallstones and certain liver diseases. Available in various forms, including tablets and syrups, UDCA is known for its ability to improve bile flow and reduce cholesterol saturation in bile.

Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid (BA) and has been administered occasionally as a hepatoprotective drug for cholestasis and chronic hepatitis; it is also the drug approved by the United States Food and Drug Administration for the treatment of primary biliary cholangitis (PBC) [10, 11].

2018年3月1日 · We found that UDCA (140 mg/kg) significantly aggravated liver injury from ANIT (100 mg/kg)-induced acute cholestasis study (data not shown). Thus, in the present study, we used 50 mg/kg ANIT for a moderate cholestasis model, and the dose of UDCA administered was selected from 25 mg/kg to 100 mg/kg.

2020年7月9日 · 全球首次上市的 UDCA 制剂为日本Mitsubishi Tanabe 公司的URSO 片剂 (50 和100mg) [1]，50 mg 片剂也是我国批准上市的国产UDCA 仿制药的主要剂型。 UDCA 用于治疗胆结石的每日常用剂量为8~10 mg·kg -1，代表制剂产品为美国Allergan 公司的Actigall胶囊剂 (300 mg) [3]；UDCA 用于治疗胆汁淤积性肝病的每日常用剂量为3~15 mg·kg -1，代表制剂产品为德国Dr. Falk Pharm 公司的Ursofalk 胶囊剂 (250 mg) [1]、美国Allergan公司的URSO 250 片剂 (250 …

Ursodeoxycholic Acid MaxSpec® Standard: A quantitative analytical standard guaranteed to meet MaxSpec^® identity, purity, stability, and concentration specifications. CAS Number: 128-13-2. Synonyms: NSC 683769, UDCA, Ursodiol. Purity: ≥95%.

Ursodeoxycholic acid (UDCA) was similarly found to offer anti-inflammatory effect and therefore may halt the ongoing dysplastic process. This review aims to examine the clinical evidence regarding the role of UDCA as a potential therapeutic agent for managing UGI disorders and as a chemopreventive agent in premalignant conditions. Methods

Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile acid it solubilizes cholesterol gallstones and improves the liver function in case of cholestatic diseases. UDCA can be obtained from cholic acid (CA), which is …

Ursodeoxycholic acid (UDCA) is known for its major effects on the liver, but its impact on autoimmune diseases is not well understood. This study aimed to assess the effectiveness of UDCA in controlling rheumatoid arthritis (RA) in an in vivo setting.

2024年4月10日 · 熊去氧胆酸 (UDCA)是一种内源性胆汁酸,具有溶解胆结石,治疗胆汁淤积、胆源性胰腺炎、原发性胆管炎、结肠炎 (癌)、 (非)酒精性肝炎、原发性胆汁性肝硬化、药物性肝炎和改善肝移植效果的作用 [1]。 最新研究发现,UDCA还可介导并影响癌症基因组中致癌信号通路调控,用于癌症治疗 [2];可特异性调控细胞凋亡阈值,诱导细胞自噬和凋亡,抑制癌细胞生长 [3];在治疗进行性神经系统疾病时,UDCA还能够改善受损线粒体功能,发挥神经保护作用 [4]。 新冠期间,UDCA还被 …