2020年8月27日 · Our finding revealed that UDCA exerted obviously favorable influence on hepatic steatosis in NAFLD rats by activating AMP-activated protein kinase (AMPK). Mechanistic studies indicated UDCA inhibited apoptosis and improved autophagy by influencing Bcl-2/Beclin-1 and Bcl-2/Bax complex interaction.

方法使用胶原蛋白II（CIA，胶原蛋白诱发的关节炎）诱导RA小鼠，通过westerblot评估疾病的严重程度或UDCA相关信号通路，例如AMP激活的蛋白激酶（AMPK）或小异二聚体伴侣亮氨酸拉链蛋白（SMILE）和免疫组化染色。

2017年8月1日 · UDCA induced the activation of AMP-activated protein kinase (AMPK) and p38 in mouse CD4 + T cells. UDCA suppressed T helper (Th)17 differentiation through upregulation of small heterodimer partner interacting leucine zipper protein (SMILE) and transcriptional activity of peroxisome proliferator-activated receptor (PPAR)γ.

2016年11月15日 · Our results showed that, both CDCA and UDCA significantly induced time- and concentration-dependent reduction in AMPK phosphorylation in SCRHs. Despite having different effects on FXR activation, CDCA and UDCA both inhibited EE-induced AMPK activation, accompanied with the up-regulation of FXR and its downstream bile acid transporters.

In this study, UDCA strongly increased AMPK phosphorylation, and UDCA-mediated SMILE gene expression was blocked by repression of AMPK signaling. However, the downstream effectors of AMPK signaling to induce SMILE gene expression remain unknown.

It was confirmed that UDCA upregulated the expression of SMILE and transcriptional activity of PPARγ via controlling AMPK or p38 activity. Conclusions: In the present study, the therapeutic effect of UDCA inducing SMILE through AMPK activation in rheumatoid arthritis mouse as well as other autoimmune disease was proposed.

2016年11月15日 · Our results showed that, both CDCA and UDCA significantly induced time- and concentration-dependent reduction in AMPK phosphorylation in SCRHs. Despite having different effects on FXR activation, CDCA and UDCA both inhibited EE-induced AMPK activation, accompanied with the up-regulation of FXR and its downstream bile acid transporters.

2018年8月1日 · Our data showed that norUDCA-activated AMPK was required for norUDCA-induced autophagy and reduced polymers of α1ATZ (Fig 5). AMPK is a Serine/Threonine kinase that plays a role in cellular energy homeostasis and activated by a rise in the ratio of AMP/ATP within the cell upon depletion of ATP .

2020年8月27日 · Our finding revealed that UDCA exerted obviously favorable influence on hepatic steatosis in NAFLD rats by activating AMP-activated protein kinase (AMPK). Mechanistic studies indicated UDCA inhibited apoptosis and improved autophagy by influencing Bcl-2/Beclin-1 and Bcl-2/Bax complex interaction.

2021年1月10日 · UDCA repaired mitochondrial dysfunction, promoted autophagy deregulation, and inhibited apoptosis - the three interactive molecular events essential for controlling neuronal survival in PD, involving the activation of AMPK/mTOR/ULK1 and PINK1/Parkin pathways.