Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria.

Ursodeoxycholic acid (UDCA) protects hepatocytes and cholangiocytes from bile acid-induced damage, such as reactive oxygen species (ROS)-induced inflammation and mitochondrial dysfunction. 1 UDCA was shown to reserve hepatocyte cell structures and stimulate anti-apoptotic pathways. 1, 2, 5, 6 It was also shown to prevent the production of ROS by...

2023年2月12日 · Ursodeoxycholic acid is a medication used to manage and treat cholestatic liver disease. This activity reviews the indications, mechanism of action, and contraindications for UDCA as a valuable agent in managing liver disease.

2024年6月26日 · Ursodiol is a type of bile acid that your body naturally forms in small amounts. When you take ursodiol as a medicine, it changes your bile so that cholesterol (a main component of gallstones)...

2025年1月7日 · Udca is used for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).

250® URSO and URSO Forte® (ursodiol) tablets are indicated for the treatment of patients with primary biliary cirrhosis (PBC). The recommended adult dosage for URSO 250® and URSO Forte® in the...

2003年11月14日 · The dihydroxy bile acid, ursodeoxycholic acid (UDCA), is increasingly being used for the treatment of chronic cholestatic liver diseases, and its pharmacodynamic effects have been reviewed in detail recently. 1–5 UDCA was identified as a major constituent of dried bile of the Chinese black bear 75 years ago, 6 and has been used for centuries ...

2006年6月1日 · Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in various cholestatic disorders. Several potential mechanisms and sites of action of UDCA have been unraveled in clinical and...

2021年8月31日 · Results: UDCA is a steroid compound with pharmacological properties. Seventeen enzymes are involved in its biosynthesis, which has been proposed in four pathways: classic, alternative, the...

Ursodeoxycholic acid (UDCA) is the therapeutic agent most widely used for the treatment of cholestatic hepatopathies of diverse etiologies and has been mainly used as a supportive treatment in cholestatic DILI.