The ursodeoxycholic acid converts lithogenic bile in non-lithogenic bile and gradually dissolves the cholesterol gallstones.

There are three principal mechanisms of UDCA action in primary biliary cirrhosis: Displacement of apolar bile acids (formation of nontoxic mixed micelles); Stabilization of the cellular membrane; Immunological action.

2024年12月4日 · Patients with abnormal liver biochemistry (regardless of histologic stage) and confirmed primary biliary cholangitis should be given ursodeoxycholic acid (UDCA). It is the chief medication used to deter disease progression.

The aim of this study was to determine the optimum dose of UDCA in early-stage PBC (stage 1 and 2). Methods: Twenty-four biopsy-proven early-stage PBC patients (one male, 23 female) received five doses of UDCA (0, 300, 600, 900, 1200 mg/day) each for 8 weeks with 4-week washout periods between doses. Symptoms (pruritus, fatigue, diarrhoea) were ...

Ursodeoxycholic acid GH. In: MIMS Online [Internet]. St Leonards (New South Wales): MIMS Australia; 2021 [cited 2021 Aug 25]. Available from: https://www.mimsonline.com.au The Royal Women's Hospital. Ursodeoxycholic acid. In: Pregnancy and Breastfeeding Medicines Guide [Internet]. Parkville (Victoria): The Royal Women's Hospital; 2020 [cited ...

2023年5月31日 · Ursodeoxycholic acid adalah obat untuk melarutkan batu empedu pada pasien yang tidak menjalani prosedur operasi. Asam ursodeoksikolat juga berguna untuk mencegah pembentukan batu empedu pada pasien dengan berat badan berlebih yang mengalami penurunan berat dengan cepat.

The daily dose depends on body weight and ranges from 1½ to 3½ film-coated tablets (14±2 mg of ursodeoxycholic acid per kg of body weight). For the first 3 months of treatment, Ursofalk 500 mg film-coated tablets should be taken divided over the day. When the liver function parameters improve, the daily dose may be taken once daily in the ...

2025年1月7日 · Udca is a naturally occurring bile acid used to treat different hepatobilliary disorders. The activity of Udca is achieved through a decrease in secretion of cholesterol in bile. Udca achieves this through a few mechanisms: it reduces cholesterol absorption, suppresses liver cholesterol synthesis and it does not inhibit bile acid synthesis.

Generic Name: ursodiol (ursodeoxycholic acid) Brand Name: Actigall, URSO, URSO 250, URSO Forte, URSO DS (CAN) Classification: Gallsone-solubilizing drug Pregnancy Category B Dosage & Route ADULTS. Solubilization of gallstones: 8–10 mg/kg/day PO given in two to three divided doses. Resolution of the gallstones requires months of therapy ...

Ursosan capsules are white hard gelatin capsules, containing a white or almost white powder. Ursosan is indicated in the treatment of chronic cholestatic liver diseases, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).