Using the principles of combinatorial chemistry, the Ugi reaction offers the possibility to synthesize a great number of compounds in one reaction, by the reaction of various ketones (or aldehydes), amines, isocyanides and carboxylic acids. These libraries can then be tested with enzymes or living organisms to find new active pharmaceutical ...

The Ugi four-component condensation (U-4CC) between an aldehyde, an amine, a carboxylic acid and an isocyanide allows the rapid preparation of α-aminoacyl amide derivatives. The Ugi Reaction products can exemplify a wide variety of substitution patterns, and constitute peptidomimetics that have potential pharmaceutical applications.

2022年3月3日 · Ugi reaction. Ugi reaction is a four-component condensation reaction of an amine, a carbonyl compound, a carboxylic acid, and an isonitrile that forms an α-acylamino amide. This reaction is also known as Ugi condensation, Ugi multicomponent condensation, Ugi multiple-component condensation, or Ugi four-component condensation.

2014年7月7日 · 一分子醛・异腈・羧酸与胺混合，得到二肽的一个四组分缩合反应（Four-component Condensation）。 该反应活性很高，通常在室温条件下几秒或者几分钟该反应就能完成。 一般极性溶剂比较适用于该反应，甲醇是最常用的溶剂。 相对于原料来说生成物溶解性比较低，所以更有利于反应的进行，并且后处理也十分方便。 路易斯酸可以加速该反应。 由于生成产物是二肽，反应速率也十分快，所以该反应经常被用于 新药探索 上。 另外可以通过变换底物 …

2020年1月7日 · The Ugi multicomponent reaction, performed by mixing an aldehyde, an amine, a carboxylic acid, and an isocyanide, is among the most important isocyanide-based multicomponent reactions (MCRs), allowing multiple bond formations (C–C and …

2013年9月19日 · Ivar Ugi (1930-2005) discover many important chemistry of isocyanides, e.g., the Ugi reaction. Isocyanide is a useful synthetic building block. Being stable carbenes, isonitriles are highly reactive compounds that can react with almost any type of reagents (electrophiles, nucleophiles and even radicals).

A convenient synthesis of highly functionalized, α,α-disubstituted amino acid amide derivatives has been accomplished by using cyclic and acyclic ketones as the carbonyl inputs in the Ugi multicomponent reaction.

2021年11月5日 · Ugi反应（乌吉反应），是指一分子醛或酮、一分子胺、一分子异腈以及一分子羧酸缩合生成α-酰氨基酰胺的多组分反应。 反应由德国化学家 Ivar Karl Ugi 于1959 年首先报道。

the Ugi Reaction •Rxn is exothermic and usually complete in seconds-minutes at room temperature •Aprotic, polar solvents are best, though the low-molecular weight alcohols have been used •Can be performed in biphasic media •High (0.5-2M) reactant concentrations are best •By virtue of the mechanism, Lewis acids can accelerate the reaction

2025年3月2日 · Ugi反应是一种非常强大的合成方法，四种反应底物一锅法在温和条件下进行缩合，广泛应用于组合化学，底物的 各个基团可以有各种变换，生成的肽类似物可能是有用的潜在的药物中间体。