2024年12月25日 · UGT1A8 (UDP Glucuronosyltransferase Family 1 Member A8) is a Protein Coding gene. Diseases associated with UGT1A8 include Crigler-Najjar Syndrome, Type I and Bilirubin Metabolic Disorder. Among its related pathways are Drug ADME and Metapathway biotransformation Phase I and II.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases.

该基因编码一种 UDP-葡萄糖醛酸转移酶，一种葡萄糖醛酸化途径的酶，可将类固醇、胆红素、激素和药物等亲脂性小分子转化为水溶性、可分泌的代谢物。 该基因是编码多种 UDP-葡糖醛酸转移酶的复杂基因座的一部分。 该基因座包括十三个独特的备用第一外显子，后跟四个共同外显子。 四个交替的第一外显子被认为是假基因。 其余九个 5' 外显子中的每一个都可以剪接至四个共同外显子，从而产生具有不同 N 末端和相同 C 末端的九种蛋白质。 每个第一外显子编码底物结合 …

2025年2月8日 · Results show UGT1A8 mRNA expression in primary hepatocytes by semi-quantitative RT-PCR. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.

Data suggest UGT1A8 is involved in differential metabolism of dietary flavonoids (glucosides and aglycones); glucuronidation of flavonoid glucosides is considerably slower than glucuronidation of flavonoid aglycones in microsomes of intestine/liver.

UGT1A1 is the first glucuronidation enzyme that was delineated as a CAR target gene through recognizing and binding to a distal phenobarbital-responsive enhancer module of UGT1A1 (gtPBREM) [77].

Incubation of the DHT monoglucuronide with 12 cDNA-expressed recombinant human UGT isoforms and uridine 5'-diphosphoglucuronic acid resulted in a low but measurable DHT diglucuronidation activity primarily with UGT1A8, a gastrointestinal UGT, and to a lesser extent with UGT1A1 and UGT1A9.

2024年1月25日 · Go to complete Gene record for UGT1A8; Go to Variation Viewer for UGT1A8 variants; Summary. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases.

Semi-quantitative RT-PCR analysis of UGT1A8 and –1A10 mRNA expression was carried out with untreated primary human hepatocytes and those exposed to Rif and 3-MC. We found that in these hepatocytes, mRNA for UGT1A8 and –1A10, was expressed at low levels and significantly induced by the addition of 3-MC or Rif to the medium.