2024年12月25日 · UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Diseases associated with UNC5B include Hyperinsulinemic Hypoglycemia, Familial, 3 and Epilepsy. Among its related pathways are Nervous system development and Netrin-1 signaling. An important paralog of this gene is UNC5C. Receptor for netrin required for axon guidance.

2021年8月11日 · We show that UNC5B-Δ8 is a constitutively pro-apoptotic splicing isoform insensitive to Netrin-1 and required for specific blood vessel development in an apoptosis-dependent manner. Like NOVA2,...

2004年10月27日 · We show here that the repulsive netrin receptor UNC5B is expressed by endothelial tip cells of the vascular system. Disruption of the Unc5b gene in mice, or of Unc5b or netrin-1a in...

2022年3月4日 · Here, we show that the endothelial Unc5B receptor controls BBB integrity by maintaining Wnt/β-catenin signaling. Inducible endothelial-specific deletion of Unc5B in adult mice leads to BBB leak...

近日，美国耶鲁大学的研究人员在 Nature Communications 期刊发表了题为：Endothelial Unc5B controls blood-brain barrier integrity 的研究论文。 该研究首次揭开了调控血脑屏障的分子机制，血管内皮细胞的受体Unc5B通过调控 Wnt信号通路 来维持血脑屏障的完整。

2025年1月4日 · UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53. Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in papillary thyroid cancer via sponging miR-129-5p. The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells.

这种特殊的蛋白质介导 netrin-1 的排斥作用，是一种血管 netrin 受体。 这种编码的蛋白质也属于一组称为依赖性受体 (DpRs) 的蛋白质，它们参与促凋亡和抗凋亡过程。 许多 DpR 参与胚胎发生和癌症进展。 已经描述了该基因的两个选择性剪接的转录物变体。 [RefSeq 提供，2011 年 10 月] This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor.

UNC-5 netrin受体B（UNC5B）是netrin-1的依赖性受体，在介导血管生成和肿瘤发生中起重要作用。 尽管UNC5B具有如此重要的作用，但目前对UNC5B在骨生成中所起的作用仍知之甚少。

2025年1月15日 · The transmembrane receptor Unc5b, a vascular-specific axon guidance receptor, is upregulated in foam cells, and inhibits their migration from the plaques. However, the mechanisms underlying Unc5b's regulation of foam cell production and retention within plaques, along with its downstream signaling pathways, remain insufficiently understood.

2009年3月27日 · To provide a foundation for the elucidation of the UNC5-mediated signaling mechanism, we determined the crystal structure of the cytoplasmic portion of UNC5b. We found that it contains three distinctly folded domains, namely ZU5, UPA, and death domain (DD).