Here, we show that the endothelial Unc5B receptor controls BBB integrity by maintaining Wnt/β-catenin signaling. Inducible endothelial-specific deletion of Unc5B in adult mice leads to BBB leak from brain capillaries that convert to a barrier-incompetent state with reduced Claudin-5 and increased PLVAP expression.

2024年6月13日 · Here, we demonstrate that UNC5B is rapidly regulated in endothelial cells in response to Notch signaling and that loss of UNC5B recapitulates Notch loss-of-function phenotypes such as increased...

2022年3月4日 · Inducible endothelial-specific deletion of Unc5B in adult mice leads to BBB leak from brain capillaries that convert to a barrier-incompetent state with reduced Claudin-5 and increased PLVAP...

2021年8月11日 · We show that UNC5B-Δ8 is a constitutively pro-apoptotic splicing isoform insensitive to Netrin-1 and required for specific blood vessel development in an apoptosis-dependent manner. Like NOVA2,...

2024年12月25日 · UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Diseases associated with UNC5B include Hyperinsulinemic Hypoglycemia, Familial, 3 and Epilepsy. Among its related pathways are Nervous system development and Netrin-1 signaling. An important paralog of this gene is UNC5C. Receptor for netrin required for axon guidance.

2025年3月12日 · Representative images of decreased regional cerebral blood flow (rCBF) using laser speckle imaging (A, yellow color) and pale appearance using TTC staining (B, arrow) in the right cortex 24 h after PT. Ntn1 supplementation or UNC5b knockdown by siUNC5b decreased neurological deficit and infarcted volume when compared to the corresponding ...

2025年1月15日 · Unc5b regulates inflammation and migration capability of macrophage-derived foam cells via P53-cuproptosis signaling pathway. The P53-cuproptosis signaling pathway inhibition attenuated atherosclerosis. Atherosclerosis involves the buildup of macrophage-derived foam cells in the arterial intima.

2022年3月4日 · Inducible endothelial-specific deletion of Unc5B in adult mice leads to BBB leak from brain capillaries that convert to a barrier-incompetent state with reduced Claudin-5 and increased PLVAP expression. Loss of Unc5B decreases BBB Wnt/β-catenin signaling, and β-catenin overexpression rescues Unc5B mutant BBB defects.

MCE提供UNC5B 蛋白, Human (HEK293, hFc)，UNC5B 是一种重要的 netrin 受体，在神经系统发育过程中介导轴突排斥，并与 DCC 结合以触发信号通路。 它对血管生成中的血管分支进行负调节，诱导尖端细胞丝状伪足回缩。

UNC-5 Homolog B (UNC5b), a dependence receptor of netrin-1, plays an essential role in mediating the repulsive effect of axonal migration and blood vessel formation through association with its ligand netrin-1 (NTN1) 19, 20.