Myeloma cells secrete monoclonal protein (m-protein) into the blood and sometimes urine. Freelite, UPEP and SPEP tests measure m-protein. Read more.

The monoclonal gammopathies (paraproteinemias or dysproteinemias) are a group of disorders characterized by the proliferation of a single clone of plasma cells, which produces an immunologically homogeneous protein commonly referred to as a paraprotein or monoclonal protein (M protein, where the "M" stands for monoclonal).

2005年1月1日 · Serum protein electrophoresis is used to identify patients with multiple myeloma and other serum protein disorders. Electrophoresis separates proteins based on their physical properties, and...

2010年12月28日 · The M-protein spike detected by UPEP or SPEP is actually made up of monoclonal light chains, so they definitely can detect light chains. IFE on the other hand detects the subtype of monoclonal light chain being produced Kappa vs Lambda.

2024年10月24日 · SPEP measures levels of five protein types: Each protein moves at its own speed and groups together when exposed to an electric current, creating specific patterns. As part of the test process, each component is separately examined and compared with amounts that are found in healthy individuals.

Serum protein electrophoresis (SPEP) is a test that measures the antibodies in the blood and can find a monoclonal antibody. Another test, called immunofixation or immunoelectrophoresis, can be used to determine the exact type of abnormal antibody (IgG, IgA, or some other type).

2011年5月10日 · Basically, SPEP has a sensitivity of ~80% for multiple myeloma, and sensitivity is increase to >95% with addition of Serum immunofixation and UPEP/Urine Immunofixation, as ~20% of multiple myeloma patients secrete ONLY light …

SPEP checks for the presence of M-protein in the blood. M-protein is an immunoglobulin that is found in high amounts in a person with multiple myeloma. UPEP checks for the presence of M-protein in urine that has been collected over 24 hours.

• Order an SPEP when suspecting disorders associated with monoclonal gammopathy (esp myeloma) • Low risk MGUS has very low risk of progression to myeloma • When monoclonal protein identified, look for CRAB symptoms or one of the new myeloma defining events • Survival in myeloma has improved tremendously due to new treatment options

Serum protein electrophoresis (SPEP) and urine protein electrophoresis (UPEP) are tests in which proteins in blood and urine samples are separated so that individual antibodies can be identified and quantified.