2024年12月25日 · UPK3A (Uroplakin 3A) is a Protein Coding gene. Diseases associated with UPK3A include Renal Hypodysplasia/Aplasia 3 and Renal Hypodysplasia/Aplasia 1. Among its related pathways is Bladder cancer. An important paralog of this gene is UPK3B.

Uroplakin-3a (UP3a) is a protein that in humans is encoded by the UPK3A gene. [5] [6] UP3a is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full. [7] It is also found in the renal pelvis, ureter, and prostatic urethra.

2024年12月10日 · UP3A; UPK3; UPIII; UPIIIA. This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

We want to evaluate prospectively the early detection power of human uroplakin 3 A (UPK3A) for bladder cancer. Methods: Urine samples were obtained from 32 healthy volunteers, 44 patients with benign urological disorders and 122 patients with bladder cancer. The urine UPK3A levels were quantified by enzyme-linked immunosorbent assay.

该基因编码 uroplakin 家族的一个成员，这是一组在膀胱上皮细胞顶端形成复合物的跨膜蛋白。 该基因的突变可能与肾发育不良有关。 已经描述了可变剪接的转录变体。 [RefSeq 提供，2009 年 11 月] This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia.

De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure. Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans. Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma.

Western blot analysis detected UPK3A at an apparent molecular mass similar to that of 47-kD bovine Upk3. Electron microscopy revealed that AUMs isolated from cattle, dog, mouse, and monkey were 12-nm protein particles forming hexagonally packed crystalline patches.

Located in apical plasma membrane urothelial plaque. Is expressed in several structures, including alimentary system; lung; male reproductive system; notochord; and urinary system. Used to study vesicoureteral reflux. Orthologous to human UPK3A (uroplakin 3A). [provided by Alliance of Genome Resources, Apr 2022]

High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway. UPIIIa is a biomarker for bladder cancer that is unrelated to chemical carcinogenesis; High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer.

我们前期通过生物信息学在人全基因组范围筛选，并通过实验验证，确定一个膀胱癌高表达基因UPK3A。 研究发现：UPK3A早期诊断膀胱癌优于目前临床应用的NMP22和尿细胞学。 UPK3A的高表达是否促进了膀胱癌的发生、发展？ 高表达的UPK3A是通过影响哪些基因或蛋白促进膀胱癌的发生、发展？ UPK3A在膀胱癌中表达升高的分子机理是什么？ 这些都是非常重要的科学问题。 我们计划从UPK3A初步功能研究、与其它蛋白相互作用、转录调控机制方面进行研究，确定 …