2018年2月9日 · One such pathway is the mitochondrial unfolded protein response (UPR mt), which is regulated by the mitochondrial import efficiency of the transcription factor ATFS-1 in C. elegans and...

Pena 等人的研究发现ATFS-1 可激活UPRmt,有效降低缺氧反应产生的致死率,ATFS-1的线粒体输入效率是细胞感知、监测、维持线粒体健康网络的调控因素之一[24, 25]。

2012年6月14日 · In addition to a nuclear localization sequence (NLS), ATFS-1 has a mitochondrial targeting sequence (MTS) that is necessary for UPRmt repression. ATFS-1 is normally imported efficiently into mitochondria and degraded by the Lon protease.

2021年1月20日 · The mitochondrial unfolded protein response (UPRmt) is a signaling pathway mediated by the transcription factor ATFS-1 which harbors a mitochondrial targeting sequence (MTS).

2024年2月15日 · ATFS-1 regulates a broad transcriptional response during stress that helps recover mitochondrial function by promoting mitochondrial proteostasis, detoxification of ROS, and metabolic restructuring, among others [26], [28]. The regulation of ATFS-1 is tightly connected with the ability of mitochondria to import proteins (Fig. 1A).

2024年10月4日 · 作为UPR mt 的关键调控因子，ATFS-1具有核定位序列、C端亮氨酸拉链结构域和N末端线粒体靶向序列。 在正常情况下，ATFS-1被转运到线粒体基质后，被LONP-1蛋白酶降解。

2015年4月2日 · To better understand genome coordination and OXPHOS recovery during mitochondrial dysfunction, we examined ATFS-1, a transcription factor that regulates mitochondria-to-nuclear communication during the mitochondrial UPR, via ChIP-sequencing.

2022年12月27日 · Here we show that the bZIP (basic leucine zipper) protein ATFS-1, a mediator of the mitochondrial unfolded protein response (UPRmt), is required to promote growth and establish a functional germline after prolonged starvation.

2023年1月2日 · To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial stress signal is sensed and relayed to UPRmt t …

2022年7月4日 · 研究团队在对prp-19调控UPRmt的分子机制进行探索的过程中发现，prp-19 敲低能直接抑制细胞核定位的ATFS-1对其下游效应基因hsp-60（编码线粒体伴侣蛋白）的转录激活，此外ATFS-1 ChIP-seq以及RNA-seq数据分析结果显示，对于在线粒体应激条件下表达上调，且 …