Uremic platelet dysfunction - UpToDate
2024年9月5日 · Impaired platelet function is one of the main determinants of abnormal bleeding in patients with a low glomerular filtration rate (GFR). Although often referred to as "uremic bleeding," bleeding in this setting generally occurs in patients who do not have clinical symptoms or signs of uremia.
Uremic bleeding syndrome - WikEM
Increased risk for of bleeding (GI, ICH, liver hematoma) due to impaired platelet function; Uremic toxins inhibit platelet aggregation Disrupts vWF; PT/PTT normal, but bleeding time elevated; Clinical Features. Wide range of presentations Ecchymosis, purpura, epistaxis, fistula bleeding, venipuncture bleeding; GI bleeding; Intracranial bleeding
15. Uremic Bleeding | Hospital Handbook - UCSF Hospitalist …
Typically cutaneous bleeding, including easy bruising and mucosal bleeding. Less commonly manifests as epistaxis or hematuria. Therapy is indicated in patients with renal failure who are actively bleeding or who are about to undergo a surgical procedure.
Uremic bleeding: pathogenesis and therapy - PubMed
Results: The most common hemorrhagic manifestations in uremia are prolonged bleeding from puncture sites; nasal, gastrointestinal and genitourinary bleeding; and subdural hematomas. The most useful clinical laboratory test to assess both bleeding risk and response to …
Evidence-based treatment recommendations for uremic bleeding
2007年6月1日 · Uremic bleeding syndrome is a recognized consequence of renal failure and can result in clinically significant sequelae. Although the pathophysiology of the condition has yet to be fully...
Uremic bleeding: Pathophysiology and clinical risk factors
2006年1月1日 · In this review, we discuss the principal clinical sites of bleeding in uremic patients, the pathophysiology and possible mechanisms of uremic bleeding, and clinical risk factors for bleeding in the uremic patient.
In this review, we discuss the principal clinical sites of bleeding in uremic patients, the patho-physiology and possible mechanisms of uremic bleeding, and clinical risk factors for bleeding in the uremic patient.
Uremic Bleeding: Pathogenesis and Therapy - ScienceDirect
1998年8月1日 · We reviewed current understanding of the pathophysiology of the uremic bleeding diathesis and discuss ac-cepted therapeutic interventions that minimize the risk of bleeding in the uremic patient.
Uremic Bleeding: Pathogenesis and Therapy - ScienceDirect
1998年8月1日 · The most common hemorrhagic manifestations in uremia are prolonged bleeding from puncture sites; nasal, gastrointestinal and genitourinary bleeding; and subdural hematomas. The most useful clinical laboratory test to assess both …
Evidence-based treatment recommendations for uremic bleeding
This article is a review of both the normal hemostatic and homeostatic mechanisms that operate within the body to prevent unnecessary bleeding, as well as an in-depth discussion of the dysfunctional components that contribute to the complications …