Interstate 81 (I-81) is a north–south (physically northeast–southwest) Interstate Highway in the eastern part of the United States.

The I-81 Interstate 81 Highway is a major automotive & trucking transportation corridor and interstate highway that travels generally in a north/northeast-south/southwest direction along the eastern inland coast of the USA.

81號州際公路（ Interstate 81 ，簡稱I-81）是美國 州際公路系統的一部份。 北接 加拿大 安大略401省道 ，南至 田納西州 丹德里治 （Dandridge）。 全長854.89英里（1375.81公里）。

U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and is one of the original United States Numbered Highways established in 1926 by the American Association of State Highway Officials.

I-81 runs along the US highway from east of Bristol, Virginia to Upstate New York, with the exception of between Harrisburg and Wilkes-Barre, Pennsylvania. Through Tennessee, U.S. 11 partitions into the branches of 11E and 11W, along the …

Interstate 81 enters the state of New York near Binghamton. It follows U.S. Route 11 in a north–south direction, through much of the state. It serves the cities of Syracuse (where it intersects the New York State Thruway), and Watertown.

Interstate 81 (abbreviated I-81) is an interstate highway in the eastern part of the United States. Its southern terminus is at Interstate 40 near Dandridge, Tennessee; its northern terminus is on Wellesley Island (near Fishers Landing, New York) at the Canadian border, where the Thousand Islands Bridge connects it to Highway 401, the main ...

Interstate 81 (I-81) is a north–south Interstate Highway in the eastern part of the United States. Its southern terminus is at I-40 in Dandridge, Tennessee; its...

Interstate 81 (abbreviated I-81) is an interstate highway in the eastern part of the United States. Its southern terminus is at Interstate 40 near Dandridge, Tennessee; its northern terminus is on Wellesley Island (near Fishers Landing, New York) at the Canadian border, where the Thousand Islands Bridge connects it to Highway 401, the main ...

2025年2月13日 · The I-81 Connect mobile app is an innovative tool for residents to stay informed about the I-81 project, providing real-time updates on daily commutes and even job opportunities, enhancing their interaction with the project. I thank Governor Hochul, Commissioner Dominguez and the 81 Project team for developing this new resource."