2024年12月25日 · USP12 (Ubiquitin Specific Peptidase 12) is a Protein Coding gene. Diseases associated with USP12 include Machado-Joseph Disease and Aplastic Anemia. Among its related pathways are Deubiquitination and Metabolism of proteins.

2023年9月26日 · In this review, we initially introduce the structure and biological functions of USP12 briefly and summarize multiple substrates of USP12 as well as the underlying mechanisms. Moreover, we discuss the influence of USP12 on tumorigenesis, tumor immune microenvironment (TME), disease, and related signaling pathways.

在这篇综述中，我们首先简要介绍了usp12的结构和生物学功能，并总结了usp12的多种底物及其潜在机制。此外，我们还讨论了usp12对肿瘤发生、肿瘤免疫微环境（tme）、疾病和相关信号通路的影响。

2021年5月3日 · In this study, we identified DUB ubiquitin-specific peptidase 12 (USP12) as a critical regulator of CD4 + T cell activation. USP12 plays an intrinsic role in promoting the CD4 + T cell...

2021年8月11日 · Downregulation of USP12 promotes lung tumour growth and fosters an immunosuppressive microenvironment with increased macrophage recruitment, hypervascularization, and reduced T cell activation. Mechanistically, USP12 downregulation creates a tumour-promoting secretome resulting from insufficient PPM1B deubiquitination that causes NF-κB ...

2025年1月4日 · USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress. USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2. USP12 positively regulates M-MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65.

2023年7月6日 · In this study, we found that knockout or knockdown of USP12 impaired the HSV-1-induced expressions of IFN-β, CCL-5, IL-6, and downstream interferon-stimulated genes (ISGs). Moreover, USP12 deficiency increased HSV …

2023年9月26日 · In this review, we initially introduce the structure and biological functions of USP12 briefly and summarize multiple substrates of USP12 as well as the underlying mechanisms. Moreover, we discuss the influence of USP12 on tumorigenesis, tumor immune microenvironment (TME), disease, and related signaling pathways.

Ubiquitous expression in brain (RPKM 15.7), lymph node (RPKM 15.4) and 25 other tissues. 启用半胱氨酸型内肽酶活性和硫醇依赖性去泛素化酶。 参与蛋白质去泛素化。 预测位于核质中。 预计在胞质溶胶和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月] Enables cysteine-type endopeptidase activity and thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm.

2021年11月11日 · In this study, through screening a series of DUBs related to breast cancer distant metastasis-free survival (DMFS) in the Kaplan-Meier Plotter database, we identified ubiquitin-specific protease 12...