Ute Galm 1 , Martin H Hager, Steven G Van Lanen, Jianhua Ju, Jon S Thorson, Ben Shen Affiliation 1 Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.

Ute Galm is a molecular microbiologist with 10+ years of experience in strain engineering, synthetic biology, and industrial biotechnology and is the Vice President of Enzyme and Strain Development at Curie Co.

Ute Galm, Evelyn Wendt-Pienkowski, Liyan Wang, Nicholas P. George, Tae-Jin Oh, Fan Yi, Meifeng Tao, Jane M. Coughlin, Ben Shen. The biosyntheticgene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from …

Specific topics addressed include: i) the mobilisation of biosynthetic gene clusters using different vector systems; ii) the selection of suitable model heterologous hosts; iii) the requirement of post-translational protein modifications and precursor supply within the model hosts; iv) the influence of promoters and pathway regulators; and v) th...

Nearly 200 oral and about 120 poster presentations kept the approximately 600 participants busy for more than 4 days. This report focuses on the 35 talks dedicated to natural products chemistry, biosynthesis, engineering, drug discovery and development, as well as neutraceuticals.

Ute Galm's 18 research works with 1,259 citations and 3,088 reads, including: BlmB and TlmB Provide Resistance to the Bleomycin Family of Antitumor Antibiotics by N -Acetylating...

博来霉素 (BLM) 是一种重要的临床抗肿瘤化合物，其类似物很难通过化学合成制备。 生产者菌株中生物合成途径的基因工程将提供一种在体内产生这种复杂分子的新衍生物的有效和方便的方法。 然而，近 20 年来，产生 BLM 的轮状链霉菌 ATCC15003 一直无法通过所有方法将质粒 DNA 引入其细胞。 在克隆和鉴定博来霉素生物合成基因簇数年后，该研究首次证明了通过属间大肠杆菌-链霉菌共轭对该药学相关生产菌株的遗传可及性。 基因替换和框内缺失突变体是通过 …

We now report that inactivation of tlmK in S. hindustanus abolished TLM A and TLM B production, the resultant Δ tlmK mutant instead accumulated five new metabolites, and introduction of a functional copy of tlmK to the Δ tlmK mutant restored TLM A and TLM B production.

Ute Galm Senior Biotech Leader | Synthetic Biology | Project Management | Helping companies enhance microbial production systems 4w Report this post ...