2022年1月8日 · 北京大学第一医院泌尿外科联合深圳市第二人民医院在Advanced Science期刊发表研究首次建立了临床肿瘤组织来源的上尿路尿路上皮癌（UTUC）类器官培养体系，极大提高了肿瘤类器官建成的成功率

2024年3月18日 · Upper tract urothelial carcinoma (UTUC) is defined as urothelial carcinoma (UC) arising from the ureter or the renal pelvis. UTUC is a rare tumor type compared...

Upper tract urothelial carcinomas (UTUCs) are rare entities that are usually diagnosed at advanced stages. Research on UTUC pathobiology and clinical management has been hampered by the lack of models accurately reflecting disease nature and diversity. In this study, a modified organoid culture syst …

2021年6月14日 · Sequencing of urine sediment-derived DNA has a high diagnostic value for UTUC with 82.2% sensitivity and 100% specificity. These results provide a solid basis for better diagnosis and management of UTUC.

Using RNA sequencing data for 100 nephroureterectomy specimens, the authors developed a five-class transcriptomic classification specific to UTUC. They examined how these RNA-based subtypes aligned with genomic features identified via …

2021年3月2日 · We sought to apply this technology to better characterize UTUC and the TME. Methods: Single cell RNA sequencing (scRNA-seq) was performed on nine UTUC tissue specimens from six different patients collected fresh via ureteroscopic biopsy using an established institutional process and the 10X Genomics platform.

2021年6月14日 · A comprehensive genomic characterization of a large, high-quality cohort of upper tract urothelial carcinomas (UTUCs) in this issue of Cancer Cell reveals that UTUCs can be divided into five DNA-based molecular subtypes. Feasibility data establish that molecular subtyping can be performed non-invasively by sequencing tumor DNA in urine.

We report the current data on the molecular alterations specific to upper tract urothelial carcinoma (UTUC), resulting from novel genomic and proteomic technologies. Although UTUC biology is comparable with that of bladder cancer, the rates and UTUC-enriched alterations support its uniqueness and th …

上尿路尿路上皮癌（upper urinary tract urothelial carcinoma，UTUC）包括肾盂癌和输尿管癌，与膀胱癌同属尿路上皮癌。 UTUC发病年龄多为50~70岁，占全部尿路上皮癌的5%~10%。 上尿路上皮癌与膀胱癌有许多类似的临床病理特征，但是UTUC本身也有其特殊点。

2024年11月24日 · UTUC属于相对少见的尿路上皮癌类型，全球年发病率为2/10万，约占所有UC的10%。 但中国2018年UTUC协作组分析了来自全国32家单位的调查数据显示，UTUC占比17.9%，高于全球比例。