Nat Commun：蛋白激酶N或能作为治疗人类心力衰竭的新型靶点
pkn酶能参与引起心脏纤维化激活的信号级联反应，这篇研究报告中，研究人员推测pkn或许参与到了纤维化过程中成纤维细胞向肌成纤维细胞的转变中 ...
Molecular insights into the regulatory landscape of PKC-related …
2024年8月1日 · Active structures of AGC kinases crystallized so far have the conserved C-terminal HM (Phe-Xaa-Xaa-Phe-Asp-Tyr) intramolecularly bound to the PIF-pocket of each …
Protein kinase N promotes cardiac fibrosis in heart failure by ...
2024年9月12日 · Fibroblast-specific deletion of PKN led to a reduction of myocardial fibrotic changes and cardiac dysfunction in mice models of ischemia-reperfusion or heart failure with …
蛋白激酶 N 通过成纤维细胞向肌成纤维细胞的转化促进心力衰竭中 …
成纤维细胞特异性删除 PKN 可减少射血分数保留的缺血再灌注或心力衰竭小鼠模型中的心肌纤维化变化和心功能障碍。 我们的结果表明 PKN 是心力衰竭中心脏纤维化的治疗靶点。 Chronic …
Fragmentation of Protein Kinase N (PKN) in the Hydrocephalic Rat …
2007年8月8日 · Correlation of PKN fragmentation with ventricular dilatation and functional impairment. We investigated the relationship between PKN fragmentation and impairment that …
Activation of PKN Mediates Survival of Cardiac Myocytes in the …
2010年7月1日 · To evaluate the role of PKN in mediating cell survival and death in response to oxidative stress, cardiac myocytes were transduced with Ad-PKN, Ad-DNPKN, or Ad-sh-PKN …
Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction
2019年11月19日 · Results: We demonstrated that RHOA activates 2 members of the PKN family of proteins, PKN1 and PKN2, in cardiomyocytes of mice with cardiac dysfunction. …
PKC and PKN in heart disease - PMC - PubMed Central (PMC)
Kinases of the PKC and closely related PKN families play multifaceted roles during cardiac development and in the pathophysiology of many cardiovascular diseases. Their crucial …
The structure and function of PKN, a protein kinase having a …
PKN is the first identified serine/threonine protein kinase that can bind to and be activated by a small GTPase Rho, and it can also be activated by fatty acids such as arachidonic acid in …
蛋白激酶N通过使心肌相关转录因子A磷酸化并破坏其与肌动蛋白的 …
与rhoa相关的蛋白激酶（rock / rho激酶）是受小gtpase rhoa调节的效应子，引起蛋白的病理性磷酸化，从而导致心血管疾病。rhoa还激活蛋白激酶n（pkn）；但是，pkn在心血管疾病中的作用 …
- 某些结果已被删除