2022年5月20日 · We determine whether CD47 signaling modulates IL-17-induced VCAM-1 expression and leukocyte adhesion and address the contribution of CD36 to TSP-1-mediated changes in VCAM-1 expression on vascular endothelial cells.

CD47 on affected brain endothelium may up-regulate ICAM-1, VCAM-1 and allow the infiltration of inflammatory cells. Once the signals reach the brain, CD47 can trigger cell death in both endothelium as well as neurons.

2022年5月20日 · Thus, our study identifies TSP-1:CD47 interaction as a molecular pathway that modulates IL-17-mediated VCAM-1 expression, contributing to its anti-inflammatory effect in chronic inflammatory conditions.

2020年6月19日 · We show that CD47 associates with CD11b/CD18 in the plasma membrane of PMN, and that loss of CD47 results in impaired CD11b/CD18 activation. In addition, in vitro and in vivo studies using...

2013年11月1日 · CD47 − T-cells showed significantly reduced stable arrest to both ICAM-1 and VCAM-1 compared with CD47 + cells (Figure 5, A and B). The defects in arrest were most pronounced on ICAM-1 compared with VCAM-1, whereas there was no defect in adhesion to E-selectin (Figure 5C).

2012年9月1日 · The engagement of adhesion molecules, such as VCAM-1 and ICAM-1 by their T-cell counter receptors α4β1 and αLβ2 integrins, and CD44 interacting with hyaluronan during TEM, triggers outside-in signaling in endothelial cells that results in alterations in proteins localized at cell junctions (reviewed in (5–7)).

Fewer Cd47 −/− T cells bound to VCAM‐1 without a stimulus compared with WT T cells. These results show that CD47 is necessary for TCR‐XL and chemokine‐induced LFA‐1 and VLA‐4 activation and adhesion to ICAM‐1 and VCAM‐1 under fluid shear flow conditions.

CD47, also called integrin-associated protein, has been demonstrated to associate in cis with β1 and β3 integrins. Here we test the hypothesis that CD47 regulates adhesive functions of T-cell α4β1 (VLA-4) and αLβ2 (LFA-1) in in vivo and in vitro models of inflammation.

2024年7月23日 · Mechanistically, CD47 and TSP1 ligation triggers G i - and PKA-dependent phosphorylation of the α4 integrin cytoplasmic domain and promotes Src-dependent sickle RBC adhesion to VCAM-1 ...

2022年5月20日 · Thus, our study identifies TSP-1:CD47 interaction as a molecular pathway that modulates IL-17-mediated VCAM-1 expression, contributing to its anti-inflammatory effect in chronic inflammatory...