VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial …
2025年1月15日 · NF-κB p65 is known to be a transcriptional activator of S100A16 (Jiang et al., 2021). Here, we validated the binding between p65 and S100A16 in HL-1 cells. We …
VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial …
Importantly, we showed that I/R and H/R treatment upregulated the expression of voltage-dependent anion channel 1 (VDAC1), which subsequently activated NF-κB/p65 to facilitate the …
VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial …
2025年1月15日 · Elevated VDAC1 triggered the activation of NF-κB p65, with an upregulated p65 subunit. After translocation to the nucleus, p65 fostered the expression of S100A16, ultimately …
Targeting the overexpressed mitochondrial protein VDAC1 in a …
2022年12月28日 · As a key protein serving as the mitochondrial gatekeeper, the voltage-dependent anion channel-1 (VDAC1) that controls metabolism and Ca 2+ homeostasis is …
Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and …
2018年12月8日 · We demonstrated that silencing VDAC1 expression using human-specific siRNA (si-hVDAC1) inhibited cancer cell growth, both in vitro and in mouse xenograft models of …
VDAC1 at the crossroads of cell metabolism, apoptosis and cell …
VDAC1 functions in the release of apoptotic proteins located in the mitochondrial intermembrane space via oligomerization to form a large channel that allows passage of cytochrome c and …
VDAC1-NF-κB/p65-mediated S100A16 contributes to... : European …
Importantly, we showed that I/R and H/R treatment upregulated the expression of voltage-dependent anion channel 1 (VDAC1), which subsequently activated NF-κB/p65 to facilitate the …
VDAC1-NF-κB/p65-mediated S100A16 contributes to ... - Europe …
2024年11月28日 · VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial ischemia/reperfusion injury by regulating oxidative stress and inflammatory response via …
VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial …
VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial ischemia/reperfusion injury by regulating oxidative stress and inflammatory response via Calmodulin/CaMKK2/AMPK pathway.
mtDNA release promotes cGAS-STING activation and accelerated …
2024年7月23日 · Voltage-dependent anion channel 1 (VDAC1) is the most abundant protein localized at mitochondrial outer membrane [27], and VDAC1 oligomerization was found to …
Non-canonical STING–PERK pathway dependent epigenetic …
2023年12月1日 · VDAC1, the most abundant VDAC isoforms, has been reported to form the large mitochondrial outer membrane pores under mitochondrial stress via oligomers, which are …
线粒体 VDAC1：炎症相关疾病的潜在治疗靶点和临床机会,Cells - X …
2022年10月10日 · vdac1 调节线粒体 ca 2+运输、脂质代谢和线粒体自噬，参与炎症相关疾病的发病机制。 许多科学家提出了通过特定靶向疗法来处理炎症过度反应问题的方法。
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and …
Strikingly, we identified VDAC1 (voltage-dependent anion channel 1) as a target for Parkin-mediated Lys 27 poly-ubiquitylation and mitophagy. Moreover, pathogenic Parkin mutations …
VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial …
2025年3月1日 · VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial ischemia/reperfusion injury by regulating oxidative stress and inflammatory response via …
VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial …
MedChemExpress (MCE) References: PMID: 39613175 Myocardial injury triggers intense inflammatory reactions and oxidative stress responses. S100 calcium-binding protein A16 …
Inhibition of PKC-δ retards kidney fibrosis via inhibiting ... - Nature
2024年7月7日 · In this study, we found that PKC-δ was highly upregulated in human biopsy samples and mouse kidneys with fibrosis. Rottlerin, a PKC-δ inhibitor, alleviated unilateral …
The role of the mitochondrial protein VDAC1 in inflammatory …
2022年2月2日 · We have investigated the role of the mitochondria gate-keeper protein, the voltage-dependent-anion channel 1 (VDAC1), in gastrointestinal inflammation and tested the …
The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide
2022年9月28日 · Recently, we developed VDAC1-based peptides that have multiple effects on cancer cells and tumors including apoptosis induction. Here, we designed several cell …
AAV-mediated upregulation of VDAC1 rescues the mitochondrial …
2024年4月16日 · Here, we show that the AAV-mediated upregulation of VDAC1 in the spinal cord of transgenic mice expressing SOD1 G93A completely rescues the mitochondrial respiratory …
VDAC1: A Key Player in the Mitochondrial Landscape of ... - PubMed
2024年12月30日 · Voltage-Dependent Anion Channel 1 (VDAC1) is a mitochondrial outer membrane protein that plays a crucial role in regulating cellular energy metabolism and …